Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity - PubMed (original) (raw)

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Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity

Yasuhiko Komiya et al. Gut. 2019 Jul.

No abstract available

Keywords: colorectal cancer; intestinal bacteria.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1

Detection of Fusobacterium nucleatum subspecies in paired colorectal cancer and saliva samples. (A) Schematic of the experimental procedures. AP-PCR, arbitrarily primed PCR; CRC, colorectal cancer; Fn, Fusobacterium nucleatum. See online supplementary information for more details. (B) Flowchart of the study process. FS agar, _Fusobacterium_-selective agar. (C) AP-PCR patterns detected with primer D11344. Data are representative of at least two independent experiments. Identical pairs are highlighted in yellow or blue. GL, gene ladder (0.1, 0.2, 0.3, 0.4, 0.5, 0.7, 1.0, 1.3, 1.5, 2.0, 3.0, 4.0, 5.0, 7.0, 10 and 20 kbp). Subspecies, an, nu, po and vi are F. nucleatum subsp. animalis, F. nucleatum subsp. nucleatum, F. nucleatum subsp. polymorphum and F. nucleatum subsp. vincentii, respectively.

Comment on

• The oral microbiota in colorectal cancer is distinctive and predictive.
  Flemer B, Warren RD, Barrett MP, Cisek K, Das A, Jeffery IB, Hurley E, O'Riordain M, Shanahan F, O'Toole PW. Flemer B, et al. Gut. 2018 Aug;67(8):1454-1463. doi: 10.1136/gutjnl-2017-314814. Epub 2017 Oct 7. Gut. 2018. PMID: 28988196 Free PMC article.

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