In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals - PubMed (original) (raw)
doi: 10.1016/j.apradiso.2018.05.033. Epub 2018 May 30.
Alessandra Boschi 2, Gianfranco Cicoria 3, Federico Zagni 3, Andrea Corazza 3, Licia Uccelli 4, Micòl Pasquali 4, Gaia Pupillo 5, Mario Marengo 3, Massimo Loriggiola 5, Hanna Skliarova 5, Liliana Mou 5, Sara Cisternino 5, Sara Carturan 6, Laura Melendez-Alafort 7, Nikolay M Uzunov 5, Michele Bello 6, Carlos Rossi Alvarez 5, Juan Esposito 5, Adriano Duatti 8
Affiliations
- PMID: 29936404
- DOI: 10.1016/j.apradiso.2018.05.033
In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals
Petra Martini et al. Appl Radiat Isot. 2018 Sep.
Abstract
In the last years, the technology for producing the important medical radionuclide technetium-99m by cyclotrons has become sufficiently mature to justify its introduction as an alternative source of the starting precursor [99mTc][TcO4]- ubiquitously employed for the production of 99mTc-radiopharmaceuticals in hospitals. These technologies make use almost exclusively of the nuclear reaction 100Mo(p,2n)99mTc that allows direct production of Tc-99m. In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99Mo/99mTc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example.
Keywords: (99m)Tc-radiopharmaceuticals; Cyclotron; European Pharmacopoeia; Generator; Hospital radiopharmacy; Molybdenum-100; SPECT; Technetium-99m.
Copyright © 2018 Elsevier Ltd. All rights reserved.
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