Acute Effect of Empagliflozin on Fractional Excretion of Sodium and eGFR in Youth With Type 2 Diabetes - PubMed (original) (raw)
. 2018 Aug;41(8):e129-e130.
doi: 10.2337/dc18-0394. Epub 2018 Jun 25.
Affiliations
- PMID: 29941496
- PMCID: PMC6054503
- DOI: 10.2337/dc18-0394
Acute Effect of Empagliflozin on Fractional Excretion of Sodium and eGFR in Youth With Type 2 Diabetes
Petter Bjornstad et al. Diabetes Care. 2018 Aug.
No abstract available
Figures
Figure 1
Changes from baseline in FeNA+ and eGFR after single-dose administration of empagliflozin (n = 27), adjusted for baseline value, age, sex, HbA1c, and BMI standard deviation score. Directions of effect on FeNA+ and eGFR were consistent across the three doses of empagliflozin tested.
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References
- Zinman B, Wanner C, Lachin JM, et al. .; EMPA-REG OUTCOME Investigators . Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015;373:2117–2128 - PubMed
- Wanner C, Inzucchi SE, Lachin JM, et al. .; EMPA-REG OUTCOME Investigators . Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 2016;375:323–334 - PubMed
- Cherney DZ, Perkins BA, Soleymanlou N, et al. . Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 2014;129:587–597 - PubMed
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