Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study - PubMed (original) (raw)

. 2018 Jul;119(2):176-181.

doi: 10.1038/s41416-018-0148-0. Epub 2018 Jun 28.

Maryam Hashemian 1 2 3, Arash Etemadi 1 2, Hossein Poustchi 4, Maryam Sharafkhah 1, Farin Kamangar 1 5, Akram Pourshams 4 6, Akbar Fazeltabar Malekshah 1, Masoud Khoshnia 6 7, Abdolsamad Gharavi 6 7, Azita Hekmatdoost 8, Paul J Brennan 9, Paolo Boffetta 10, Sanford M Dawsey 2, Christian C Abnet 11, Reza Malekzadeh 12 13

Affiliations

• PMID: 29950612
• PMCID: PMC6048068
• DOI: 10.1038/s41416-018-0148-0

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study

Maryam Hashemian et al. Br J Cancer. 2018 Jul.

Abstract

Background: Nut consumption has been inversely associated with gastric cancer incidence in US-based studies, but not with oesophageal cancer. However, there is aetiologic heterogeneity, among oesophageal squamous cell carcinoma (ESCC) cases in low-risk vs. high-risk populations. The objective of this study was to evaluate the association between nut consumption and risk of ESCC in a high-risk population.

Methods: The Golestan Cohort Study enroled 50,045 participants in Northeastern Iran, between 2004 and 2008. Intake of peanuts, walnuts and mixed nuts (including seeds) were assessed using a validated food frequency questionnaire at baseline. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals for subsequent ESCC adjusted for potential confounders. Non-consumers of nuts were used as the reference category and the consumers were categorised into tertiles.

Results: We accrued 280 incident ESCC cases during 337,983 person-years of follow up. Individuals in the highest tertiles of total nut consumption, and mixed nut consumption were significantly associated with lower risk of developing ESCC compared to non-consumers (HR = 0.60, 95% CI = 0.39-0.93, p-trend = 0.02, and HR = 0.52, 95% CI = 0.32-0.84, p trend = 0.002, respectively).

Conclusions: We found a statistically significant inverse association between total nut consumption and the risk of ESCC in this high-risk population.

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Conflict of interest statement

The authors declare no competing interests.

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