An inherited limb deformity created by insertional mutagenesis in a transgenic mouse - PubMed (original) (raw)

. 1985 Nov;318(6041):36-40.

doi: 10.1038/318036a0.

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

R P Woychik et al. Nature. 1985 Nov.

Abstract

We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant mutation that gives rise to a related limb dysmorphism. The inserted element thus provides a molecular genetic link with the control of pattern formation in the mammalian embryo.

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