Replication of cytomegalovirus in human arterial smooth muscle cells - PubMed (original) (raw)
Replication of cytomegalovirus in human arterial smooth muscle cells
J J Tumilowicz et al. J Virol. 1985 Dec.
Abstract
Cytomegalovirus (CMV) strain AD-169 replicated in smooth muscle cell (SMC) cultures derived from human umbilical arteries, producing enveloped infectious virions. However, unlike the effects of CMV on fully permissive human lung fibroblasts, the effects of strain AD-169 on SMC cultures were delayed and prolonged, resulting in extended survival of a fraction of the starting population. This period of survival did not exceed the life-span of the control SMC cultures. Infectious CMV continued to be isolated from the surviving SMC cultures after extinction of the original inoculum by dilution and after treatment of the cultures with CMV neutralizing antibody. The implications of these findings for the pathogenesis of atherosclerosis are discussed.
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References
- J Exp Med. 1972 Oct 1;136(4):769-89 - PubMed
- J Cell Biol. 1963 Apr;17:208-12 - PubMed
- Proc Natl Acad Sci U S A. 1973 Jun;70(6):1753-6 - PubMed
- Lab Invest. 1975 Jul;33(1):16-27 - PubMed
- J Virol. 1975 Oct;16(4):982-90 - PubMed
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