Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III - PubMed (original) (raw)
. 1986 Feb;319(6054):555-9.
doi: 10.1038/319555a0.
- PMID: 3003584
- DOI: 10.1038/319555a0
Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III
C A Rosen et al. Nature. 1986 Feb.
Abstract
The level of synthesis of viral proteins and heterologous proteins under the control of long terminal repeat sequences of human T-lymphotropic virus type III (HTLV-III or LAV) increases dramatically in cells that constitutively express the HTLV-III trans-activator protein. Increased levels of protein synthesis occur without a comparable increase in the levels of corresponding messenger RNA. We propose that post-transcriptional events mediated by the HTLV-III trans-activator protein account for positive regulation of HTLV-III gene products in infected cells.
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