A new site of integration for mouse mammary tumor virus proviral DNA common to BALB/cf(C3H) mammary and kidney adenocarcinomas - PubMed (original) (raw)
A new site of integration for mouse mammary tumor virus proviral DNA common to BALB/cf(C3H) mammary and kidney adenocarcinomas
M Garcia et al. EMBO J. 1986 Jan.
Abstract
The BALB/cf/Cd substrain of mice, developed by inbreeding and selection, shows a 70% incidence of spontaneous kidney adenocarcinomas. Initially foster-nursed on C3H mothers, these mice no longer produce mammary tumors, but there is evidence that mouse mammary tumor virus (MMTV) is involved in the formation of these renal carcinomas. We identified a chromosomal region called int-41, representing a locus interrupted by the integration of an exogenous MMTV provirus in a BALB/c mammary tumor. We found a DNA rearrangement and transcriptional activation in the domain specified by the int-41 probe in one primary kidney adenocarcinoma. A 5.2-kb int-41 specific mRNA was detected in the kidney tumor cell line established from a transplantable renal adenocarcinoma. This mRNA hybridized with MMTV and int-41 specific probes suggesting that it is a hybrid molecule composed of MMTV-LTR sequences covalently linked to host cell RNA. This mRNA was strongly stimulated by the presence of glucocorticoid hormone in the culture medium. Our data are compatible with the hypothesis that the int-41 chromosomal domain is involved in the neoplastic transformation of epithelial cells from different organs.
Similar articles
- A rare common integration site of proviruses of the mouse mammary tumor virus in P-type mammary tumors of mouse strain GR.
Schuermann M, Michalides R. Schuermann M, et al. Virology. 1987 Feb;156(2):229-37. doi: 10.1016/0042-6822(87)90402-8. Virology. 1987. PMID: 3027974 - Retroviral insertional mutagenesis in murine mammary cancer.
Nusse R, van Ooyen A, Rijsewijk F, van Lohuizen M, Schuuring E, van't Veer L. Nusse R, et al. Proc R Soc Lond B Biol Sci. 1985 Oct 22;226(1242):3-13. doi: 10.1098/rspb.1985.0075. Proc R Soc Lond B Biol Sci. 1985. PMID: 2866522 - Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat.
Wellinger RJ, Garcia M, Vessaz A, Diggelmann H. Wellinger RJ, et al. J Virol. 1986 Oct;60(1):1-11. doi: 10.1128/JVI.60.1.1-11.1986. J Virol. 1986. PMID: 3018276 Free PMC article. - Expression of the int-1 and int-2 loci in endogenous mouse mammary tumor virus-induced mammary tumorigenesis in the C3Hf mouse.
Etkind PR. Etkind PR. J Virol. 1989 Nov;63(11):4972-5. doi: 10.1128/JVI.63.11.4972-4975.1989. J Virol. 1989. PMID: 2552179 Free PMC article. - Protoneoplasia: the molecular biology of murine mammary hyperplasia.
Cardiff RD. Cardiff RD. Adv Cancer Res. 1984;42:167-90. doi: 10.1016/s0065-230x(08)60458-3. Adv Cancer Res. 1984. PMID: 6098147 Review.
Cited by
- The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV).
Bevilacqua G. Bevilacqua G. Viruses. 2022 Aug 1;14(8):1704. doi: 10.3390/v14081704. Viruses. 2022. PMID: 36016325 Free PMC article. Review. - Isolation of a Human Betaretrovirus from Patients with Primary Biliary Cholangitis.
Goubran M, Wang W, Indik S, Faschinger A, Wasilenko ST, Bintner J, Carpenter EJ, Zhang G, Nuin P, Macintyre G, Wong GK, Mason AL. Goubran M, et al. Viruses. 2022 Apr 24;14(5):886. doi: 10.3390/v14050886. Viruses. 2022. PMID: 35632628 Free PMC article. - Genetic control of renal tumorigenesis by the mouse Rtm1 locus.
Jensen JR, Galvan A, Borrego A, Cabrera WH, Ribeiro OG, Starobinas N, De Franco M, Colecchia M, Bertolotti A, Dragani TA, Ibañez OC. Jensen JR, et al. BMC Genomics. 2013 Oct 22;14(1):724. doi: 10.1186/1471-2164-14-724. BMC Genomics. 2013. PMID: 24148528 Free PMC article. - BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.
Jones PH, Mahauad-Fernandez WD, Madison MN, Okeoma CM. Jones PH, et al. Virology. 2013 Sep;444(1-2):124-39. doi: 10.1016/j.virol.2013.05.042. Epub 2013 Jun 25. Virology. 2013. PMID: 23806386 Free PMC article. - Recent translational research: oncogene discovery by insertional mutagenesis gets a new boost.
Hilkens J. Hilkens J. Breast Cancer Res. 2006;8(1):102. doi: 10.1186/bcr1376. Epub 2006 Jan 16. Breast Cancer Res. 2006. PMID: 16469121 Free PMC article.
References
- J Virol. 1981 Dec;40(3):735-44 - PubMed
- Nature. 1981 Apr 9;290(5806):475-80 - PubMed
- Science. 1982 Sep 3;217(4563):939-41 - PubMed
- Nature. 1983 Jan 27;301(5898):290-1 - PubMed
- Cell. 1982 Nov;31(1):99-109 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases