Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial - PubMed (original) (raw)

Randomized Controlled Trial

Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial

Maurice A Recanati et al. Clin Exp Obstet Gynecol. 2018.

Abstract

Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0.01) when compared to Trichloroacetic acid.

Keywords: Cantharidin; Cantharone; randomized controlled trial; warts.

PubMed Disclaimer

Cited by

The Effectiveness of Chemical Cautery and Electrosurgery on Anogenital Wart: Systematic Review.
Mawardi P, Kamilah L, Fauziyyah Heryadi F, Arrosyid A. Mawardi P, et al. Clin Cosmet Investig Dermatol. 2023 Oct 5;16:2773-2780. doi: 10.2147/CCID.S426851. eCollection 2023. Clin Cosmet Investig Dermatol. 2023. PMID: 37818198 Free PMC article. Review.
Formaldehyde 5% in Flexible Collodion Compared to Cryotherapy for Treatment of Female Genital Warts: A Randomized Clinical Trial.
Jahromi BN, Razeghi M, Dastgheib L, Fazelzadeh A, Miri A, Vakili S, Foruhari S, Sabetian S. Jahromi BN, et al. Indian J Dermatol. 2022 Jul-Aug;67(4):478. doi: 10.4103/ijd.ijd_1035_21. Indian J Dermatol. 2022. PMID: 36578699 Free PMC article.
A Retrospective Study of Clinical Efficacy of Cantharidin Cream for Verruca Plantaris.
Wu X, Hu Y, Lu Y, Ke X, Liu K, Zhou X, Hu Y. Wu X, et al. Infect Drug Resist. 2022 Jul 27;15:4059-4063. doi: 10.2147/IDR.S375384. eCollection 2022. Infect Drug Resist. 2022. PMID: 35924013 Free PMC article.
Phase II, Double-Blind, Vehicle-Controlled Study to Determine the Cantharidin Dose Regimen, Efficacy, Safety, and Tolerability of VP-102 in Subjects with External Genital Warts.
Guenthner S, McFalda W, Tate M, Eads K, Rieger J, Glover DK, Willson C, Rumney P, Rosen T, Andres J, Olivadoti M. Guenthner S, et al. Am J Clin Dermatol. 2021 Nov;22(6):867-875. doi: 10.1007/s40257-021-00635-2. Epub 2021 Sep 13. Am J Clin Dermatol. 2021. PMID: 34515985 Free PMC article. Clinical Trial.
Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways.
Naz F, Wu Y, Zhang N, Yang Z, Yu C. Naz F, et al. Molecules. 2020 Jul 19;25(14):3279. doi: 10.3390/molecules25143279. Molecules. 2020. PMID: 32707651 Free PMC article. Review.

References

1. Hathaway JK., HPV: diagnosis, prevention, and treatment. Clin Obstet Gynecol. 2012. September;55(3):671–80. - PubMed
1. Fleischer AB Jr., et al. Condylomata acuminata (genital warts): patient demographics and treating physicians. Sex Transm Dis. 2001;28(11):643–647 - PubMed
1. Abdullah AN, Walzman M, Wade A. Treatment of External Genital Warts Comparing Cryotherapy (liquid nitrogen) and Trichloroacetic Acid. Sex Transm Dis. 1993. Nov-Dec;20(6):344–5. - PubMed
1. Yanofsky VR, Patel RV, Goldenberg G. Genital warts: a comprehensive review. J Clin Aesthet Dermatol. 2012. June;5(6):25–36. - PMC - PubMed
1. Moore RA, et al. Imiquimod for the treatment of genital warts: a quantitative systematic review. BMC Infect Dis. 2001;1:3. - PMC - PubMed

Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial - PubMed (original) (raw)