Cytomegalovirus glomerulopathy: a controversial lesion - PubMed (original) (raw)
Case Reports
Cytomegalovirus glomerulopathy: a controversial lesion
G A Herrera et al. Kidney Int. 1986 Mar.
Free article
Abstract
Seven autopsies performed on immunosuppressed bone marrow transplant recipients who died with documented herpes virus infection were reviewed. The kidneys were studied by light and electron microscopy and revealed no pathological findings, specifically no glomerulopathy or tubular interstitial nephritis. Seven renal biopsies performed on kidney transplant recipients in whom a diagnosis of cytomegalovirus glomerulopathy was entertained were also studied. These patients exhibited clinical parameters suggestive of cytomegalovirus infection. Three patients had subsequent nephrectomies and two showed severe acute vascular rejection. The one kidney without demonstrable acute vascular rejection was negative for cytomegalovirus on culture. Three additional patients improved or stabilized their renal function under therapy for rejection. Light, electron microscopic and immunofluorescent studies, although confirmatory of endothelial cell damage, did not substantiate active cytomegalovirus renal infection in these patients. An additional group of fifteen children with disseminated cytomegalovirus infection revealed no evidence of glomerulopathy. Finally, two kidney transplant recipients with proven cytomegalovirus infection (one with associated tubular interstitial nephritis) also showed no glomerular alterations. It is the author's opinion that the entity that has been considered as cytomegalovirus glomerulopathy probably represents rejection, either a peculiar anti-endothelial type of rejection or a protracted, early, or partially resolved acute vascular rejection without residual or identifiable acute vascular rejection changes in the tissue sampled.
Similar articles
- Cytomegalovirus and kidney.
Battegay EJ, Mihatsch MJ, Mazzucchelli L, Zollinger HU, Gudat F, Thiel G, Heitz PU. Battegay EJ, et al. Clin Nephrol. 1988 Nov;30(5):239-47. Clin Nephrol. 1988. PMID: 2850879 - The value of needle renal allograft biopsy. I. A retrospective study of biopsies performed during putative rejection episodes.
Matas AJ, Sibley R, Mauer M, Sutherland DE, Simmons RL, Najarian JS. Matas AJ, et al. Ann Surg. 1983 Feb;197(2):226-37. doi: 10.1097/00000658-198302000-00017. Ann Surg. 1983. PMID: 6297416 Free PMC article. - Archetype Analysis Identifies Distinct Profiles in Renal Transplant Recipients with Transplant Glomerulopathy Associated with Allograft Survival.
Aubert O, Higgins S, Bouatou Y, Yoo D, Raynaud M, Viglietti D, Rabant M, Hidalgo L, Glotz D, Legendre C, Delahousse M, Shah N, Sis B, Campbell P, Mengel M, Jouven X, Duong Van Huyen JP, Lefaucheur C, Loupy A. Aubert O, et al. J Am Soc Nephrol. 2019 Apr;30(4):625-639. doi: 10.1681/ASN.2018070777. Epub 2019 Mar 14. J Am Soc Nephrol. 2019. PMID: 30872323 Free PMC article. - [The pathology of renal transplants].
Vazquez Martul E. Vazquez Martul E. Rev Esp Patol. 2018 Apr-Jun;51(2):110-123. doi: 10.1016/j.patol.2017.10.001. Epub 2017 Nov 28. Rev Esp Patol. 2018. PMID: 29602372 Review. Spanish. - Role of electron microscopy in transplant renal pathology.
Herrera GA, Isaac J, Turbat-Herrera EA. Herrera GA, et al. Ultrastruct Pathol. 1997 Nov-Dec;21(6):481-98. doi: 10.3109/01913129709016365. Ultrastruct Pathol. 1997. PMID: 9355231 Review.
Cited by
- Virus-Associated Nephropathies: A Narrative Review.
Masset C, Le Turnier P, Bressollette-Bodin C, Renaudin K, Raffi F, Dantal J. Masset C, et al. Int J Mol Sci. 2022 Oct 10;23(19):12014. doi: 10.3390/ijms231912014. Int J Mol Sci. 2022. PMID: 36233315 Free PMC article. Review. - Cytomegalovirus glomerulopathy and cytomegalovirus interstitial nephritis on sequential transplant kidney biopsies.
Vichot AA, Formica RN Jr, Moeckel GW. Vichot AA, et al. Am J Kidney Dis. 2014 Mar;63(3):536-9. doi: 10.1053/j.ajkd.2013.08.021. Epub 2013 Oct 25. Am J Kidney Dis. 2014. PMID: 24568687 Free PMC article. - Cytomegalovirus infection and unusual early graft dysfunction in a renal transplant recipient.
Sanavi S, Ghods A, Afshar R. Sanavi S, et al. J Glob Infect Dis. 2009 Jan;1(1):77-8. doi: 10.4103/0974-777X.52990. J Glob Infect Dis. 2009. PMID: 20300395 Free PMC article. No abstract available. - Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus.
Gnann JW Jr, Ahlmén J, Svalander C, Olding L, Oldstone MB, Nelson JA. Gnann JW Jr, et al. Am J Pathol. 1988 Aug;132(2):239-48. Am J Pathol. 1988. PMID: 2840830 Free PMC article. - Cytomegalovirus replicates efficiently in human kidney mesangial cells.
Heieren MH, van der Woude FJ, Balfour HH Jr. Heieren MH, et al. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1642-6. doi: 10.1073/pnas.85.5.1642. Proc Natl Acad Sci U S A. 1988. PMID: 2830624 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical