Cachectin and tumour necrosis factor as two sides of the same biological coin - PubMed (original) (raw)
Review
. 1986 Apr;320(6063):584-8.
doi: 10.1038/320584a0.
- PMID: 3010124
- DOI: 10.1038/320584a0
Review
Cachectin and tumour necrosis factor as two sides of the same biological coin
B Beutler et al. Nature. 1986 Apr.
Abstract
In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.
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