Intracellular diffusion gradients of O2 and ATP - PubMed (original) (raw)
Review
Intracellular diffusion gradients of O2 and ATP
D P Jones. Am J Physiol. 1986 May.
Abstract
Endogenous enzymes with different subcellular localizations provide in situ probes to study O2 and ATP concentration at various sites within cells. Results from this approach indicate that substantial intracellular concentration gradients occur under some O2- and ATP-limited conditions. These studies, along with electron microscopic analyses and mathematical modeling, indicate that clustering and distribution of mitochondria are major factors in determining the magnitude and location of the concentration gradients. The mitochondria appear to be clustered in sites of high ATP demand to maximize ATP supply under conditions of limited production. The size of such clusters is limited by the magnitude of the O2 gradient needed to provide adequate O2 concentrations for mitochondrial function within the clusters. Thus microheterogeneity of metabolite concentrations can occur in cells without membranal compartmentation and may be important in determining the rates of various high-flux processes.
Similar articles
- ATP concentration gradients in cytosol of liver cells during hypoxia.
Aw TY, Jones DP. Aw TY, et al. Am J Physiol. 1985 Nov;249(5 Pt 1):C385-92. doi: 10.1152/ajpcell.1985.249.5.C385. Am J Physiol. 1985. PMID: 2998197 - Effect of mitochondrial clustering on O2 supply in hepatocytes.
Jones DP. Jones DP. Am J Physiol. 1984 Jul;247(1 Pt 1):C83-9. doi: 10.1152/ajpcell.1984.247.1.C83. Am J Physiol. 1984. PMID: 6331189 - Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport.
Lin PC, Kreutzer U, Jue T. Lin PC, et al. J Physiol. 2007 Jan 15;578(Pt 2):595-603. doi: 10.1113/jphysiol.2006.116061. Epub 2006 Oct 12. J Physiol. 2007. PMID: 17038435 Free PMC article. - Is the function of the renal papilla coupled exclusively to an anaerobic pattern of metabolism?
Cohen JJ. Cohen JJ. Am J Physiol. 1979 May;236(5):F423-33. doi: 10.1152/ajprenal.1979.236.5.F423. Am J Physiol. 1979. PMID: 220881 Review. - Intracellular compartmentation of organelles and gradients of low molecular weight species.
Aw TY. Aw TY. Int Rev Cytol. 2000;192:223-53. doi: 10.1016/s0074-7696(08)60528-8. Int Rev Cytol. 2000. PMID: 10553281 Review.
Cited by
- Diffusiophoresis promotes phase separation and transport of biomolecular condensates.
Doan VS, Alshareedah I, Singh A, Banerjee PR, Shin S. Doan VS, et al. Nat Commun. 2024 Sep 3;15(1):7686. doi: 10.1038/s41467-024-51840-6. Nat Commun. 2024. PMID: 39227569 Free PMC article. - Exercise and fatigue: integrating the role of K+, Na+ and Cl- in the regulation of sarcolemmal excitability of skeletal muscle.
Renaud JM, Ørtenblad N, McKenna MJ, Overgaard K. Renaud JM, et al. Eur J Appl Physiol. 2023 Nov;123(11):2345-2378. doi: 10.1007/s00421-023-05270-9. Epub 2023 Aug 16. Eur J Appl Physiol. 2023. PMID: 37584745 Free PMC article. Review. - Longitudinal diffusion barriers imposed by myofilaments and mitochondria in murine cardiac myocytes.
Deisl C, Chung JH, Hilgemann DW. Deisl C, et al. J Gen Physiol. 2023 Oct 2;155(10):e202213329. doi: 10.1085/jgp.202213329. Epub 2023 Aug 9. J Gen Physiol. 2023. PMID: 37555782 Free PMC article. - Mean dose rate in ultra-high dose rate electron irradiation is a significant predictor for O2consumption and H2O2yield.
Sunnerberg JP, Zhang R, Gladstone DJ, Swartz HM, Gui J, Pogue BW. Sunnerberg JP, et al. Phys Med Biol. 2023 Aug 7;68(16):165014. doi: 10.1088/1361-6560/ace877. Phys Med Biol. 2023. PMID: 37463588 Free PMC article. - Diffusiophoresis promotes phase separation and transport of biomolecular condensates.
Doan VS, Alshareedah I, Singh A, Banerjee PR, Shin S. Doan VS, et al. bioRxiv [Preprint]. 2024 Feb 17:2023.07.03.547532. doi: 10.1101/2023.07.03.547532. bioRxiv. 2024. PMID: 37461689 Free PMC article. Updated. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources