Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene - PubMed (original) (raw)
Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene
P Martin et al. EMBO J. 1986 Jul.
Abstract
We have constructed avian retroviruses expressing the human c-myc oncogene. These viruses morphologically transformed primary quail embryo fibroblasts upon transfection and infection. Transformed cells produced viruses harboring a spliced c-myc gene and contained high levels of p64-67c-myc protein. One of these infectious viruses, vSX-AHM, was molecularly cloned and the nucleotide sequence of the spliced c-myc insert determined. No mutation was found within the c-myc coding sequence of this transforming clone when compared to the normal genomic progenitor. Thus, we concluded that no mutation within the human c-myc gene is required to induce primary avian embryo fibroblast transformation.
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