Organization of the thymidylate synthase gene of herpesvirus saimiri - PubMed (original) (raw)
Organization of the thymidylate synthase gene of herpesvirus saimiri
W Bodemer et al. J Virol. 1986 Oct.
Abstract
Herpesvirus saimiri codes, unlike most other herpesviruses, for a thymidylate synthase (TS). The TS gene of herpesvirus saimiri is unusual in structure and regulation of expression. It is transcribed into a nonspliced mRNA of 2,190 nucleotides. The single open reading frame of the viral TS gene, instructing a polypeptide of 33.5 kilodaltons, has extensive sequence homology with the corresponding TS coding sequences of human cells and of various procaryotes; the putative polypeptide derived from the nucleotide sequence of the herpesvirus saimiri TS gene is 70% identical with the human enzyme. The untranslated regions of the herpesvirus saimiri TS gene do not share homology with the other characterized eucaryotic or bacterial TS genes. The 5' untranslated sequence has 22 ATG triplets shortly followed by stop codons. The herpesvirus saimiri TS gene, which may be weakly transcribed during immediate early and early times of virus replication, is maximally expressed at the late phase. Various parameters suggest that the TS gene has been acquired in virus evolution by an ancestral herpesvirus from the cellular genome.
Similar articles
- Herpesvirus saimiri.
Fickenscher H, Fleckenstein B. Fickenscher H, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):545-67. doi: 10.1098/rstb.2000.0780. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11313011 Free PMC article. Review. - trans activation of the thymidylate synthase promoter of herpesvirus saimiri.
Lang G, Fleckenstein B. Lang G, et al. J Virol. 1990 Nov;64(11):5333-41. doi: 10.1128/JVI.64.11.5333-5341.1990. J Virol. 1990. PMID: 2170674 Free PMC article. - The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.
Honess RW, Bodemer W, Cameron KR, Niller HH, Fleckenstein B, Randall RE. Honess RW, et al. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3604-8. doi: 10.1073/pnas.83.11.3604. Proc Natl Acad Sci U S A. 1986. PMID: 3012520 Free PMC article. - Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus.
Müller K, Tidona CA, Bahr U, Darai G. Müller K, et al. Virus Genes. 1998;17(3):243-58. doi: 10.1023/a:1008017820941. Virus Genes. 1998. PMID: 9926400 - Bovine herpesvirus 4: genomic organization and relationship with two other gammaherpesviruses, Epstein-Barr virus and herpesvirus saimiri.
Lomonte P, Bublot M, van Santen V, Keil G, Pastoret PP, Thiry E. Lomonte P, et al. Vet Microbiol. 1996 Nov;53(1-2):79-89. doi: 10.1016/s0378-1135(96)01236-9. Vet Microbiol. 1996. PMID: 9011000 Review.
Cited by
- Epstein-Barr virus-host cell interactions: an epigenetic dialog?
Niller HH, Szenthe K, Minarovits J. Niller HH, et al. Front Genet. 2014 Oct 21;5:367. doi: 10.3389/fgene.2014.00367. eCollection 2014. Front Genet. 2014. PMID: 25400657 Free PMC article. - Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.
Folcik VA, Garofalo M, Coleman J, Donegan JJ, Rabbani E, Suster S, Nuovo A, Magro CM, Di Leva G, Nuovo GJ. Folcik VA, et al. Mod Pathol. 2014 Jun;27(6):851-62. doi: 10.1038/modpathol.2013.198. Epub 2013 Nov 15. Mod Pathol. 2014. PMID: 24232864 Free PMC article. - Complete genome sequence of the shrimp white spot bacilliform virus.
Yang F, He J, Lin X, Li Q, Pan D, Zhang X, Xu X. Yang F, et al. J Virol. 2001 Dec;75(23):11811-20. doi: 10.1128/JVI.75.23.11811-11820.2001. J Virol. 2001. PMID: 11689662 Free PMC article. - Herpesvirus saimiri.
Fickenscher H, Fleckenstein B. Fickenscher H, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):545-67. doi: 10.1098/rstb.2000.0780. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11313011 Free PMC article. Review. - The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-transformed human T cells.
Knappe A, Hiller C, Thurau M, Wittmann S, Hofmann H, Fleckenstein B, Fickenscher H. Knappe A, et al. J Virol. 1997 Dec;71(12):9124-33. doi: 10.1128/JVI.71.12.9124-9133.1997. J Virol. 1997. PMID: 9371569 Free PMC article.
References
- Cell. 1985 Jun;41(2):349-59 - PubMed
- Nature. 1984 Nov 29-Dec 5;312(5993):473-4 - PubMed
- Proc Natl Acad Sci U S A. 1985 Apr;82(8):2315-9 - PubMed
- Virus Res. 1985 Mar;2(2):107-21 - PubMed
- Nucleic Acids Res. 1985 Mar 25;13(6):2035-43 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources