S-Nitrosoglutathione loaded poly(lactic-co-glycolic acid) microparticles for prolonged nitric oxide release and enhanced healing of methicillin-resistant Staphylococcus aureus-infected wounds - PubMed (original) (raw)
doi: 10.1016/j.ejpb.2018.09.009. Epub 2018 Sep 14.
Jihyun Kim 2, Juho Lee 1, Nurhasni Hasan 1, Jiafu Cao 1, Muhammad Naeem 1, Eun Hee Lee 3, Jae Ho Shin 4, Yunjin Jung 1, Bok-Leul Lee 1, Byung Hak Jhun 5, Jin-Wook Yoo 6
Affiliations
- PMID: 30223029
- DOI: 10.1016/j.ejpb.2018.09.009
S-Nitrosoglutathione loaded poly(lactic-co-glycolic acid) microparticles for prolonged nitric oxide release and enhanced healing of methicillin-resistant Staphylococcus aureus-infected wounds
Shwe Phyu Hlaing et al. Eur J Pharm Biopharm. 2018 Nov.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds have become a significant clinical issue worldwide. Recently, nitric oxide (NO) has emerged as a potent antibacterial agent against MRSA infections and a wound-healing enhancer. Nevertheless, clinical applications of NO have been largely restricted by its gaseous state and short half-life. In this study, our aim was to develop S-nitrosoglutathione (GSNO, an endogenous NO donor)-loaded poly(lactic-co-glycolic acid) [PLGA] microparticles (GSNO-MPs) that release NO over a prolonged period, to accelerate the healing of MRSA-infected wounds with less frequent dosing. GSNO was successfully encapsulated into PLGA microparticles by a solid-in-oil-in-water emulsion solvent evaporation method. Scanning electron microscopy and X-ray diffraction analyses confirmed the successful fabrication of GSNO-MPs. The latter released NO in a prolonged manner over 7 days and exerted a remarkable antibacterial activity against MRSA in a concentration- and time-dependent manner. Moreover, GSNO-MPs had good antibacterial efficacy and were found to accelerate wound healing in a mouse model of MRSA-infected wounds. Therefore, NO-releasing MPs devised in this study may be a promising option for the treatment of cutaneous wounds infected by drug-resistant bacteria such as MRSA.
Keywords: Methicillin-resistant Staphylococcus aureus; Nitric oxide; Poly (lactic-co-glycolic acid) microparticles; S-nitrosoglutathione; Wound healing.
Copyright © 2018 Elsevier B.V. All rights reserved.
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