Association between storage age of transfused red blood cells and clinical outcomes in critically ill adults: A meta-analysis of randomized controlled trials - PubMed (original) (raw)
Meta-Analysis
. 2019 Dec;43(9):528-537.
doi: 10.1016/j.medin.2018.07.004. Epub 2018 Sep 18.
[Article in English, Spanish]
Affiliations
- PMID: 30241932
- DOI: 10.1016/j.medin.2018.07.004
Meta-Analysis
Association between storage age of transfused red blood cells and clinical outcomes in critically ill adults: A meta-analysis of randomized controlled trials
[Article in English, Spanish]
X Zhou et al. Med Intensiva (Engl Ed). 2019 Dec.
Abstract
Objectives: A meta-analysis was performed to assesses the effect of storage age of transfused red blood cells (RBCs) upon clinical outcomes in critically ill adults.
Methods: A comprehensive search was conducted in the PubMed, OVID, Web of Science and Cochrane databases for randomized controlled trials (RCTs) comparing the transfusion of fresher versus older RBCs in critically ill adults from database inception to December 2017. The primary endpoint was short-term mortality, and the secondary endpoints were the duration of intensive care unit (ICU) and hospital stay. The pooled odds ratios (OR) and mean differences (MD) were calculated using Stata/SE 11.0.
Results: A total of six RCTs were identified, of which four were multicenter studies, while two were single-center trials. The pooled results indicated that the transfusion of fresher RBCs was not associated to a decrease in short-term mortality compared with the transfusion of older RBCs (random-effects OR=1.04, 95% confidence interval (CI): 0.96-1.13, P=0.312; I2=0.0%; six trials; 18240 patients), regardless of whether the studies were of a multi-center (random-effects OR=1.04, 95% CI: 0.96-1.13, P=0.292; I2=0.0%) or single-center nature (random-effects OR=1.16, 95% CI: 0.28-4.71, P=0.839; I2=56.7%), or with low risk of bias (random-effects OR=1.04, 95% CI: 0.94-1.16, P=0.445; I2=0.0%). In addition, the transfusion of fresher RBCs did not reduce the geometric mean duration of ICU stay (1.0% increase in geometric mean, 95% CI: -3.0 to 5.1%, P=0.638; I2=81.5%; four trials; 7550 patients) or the geometric mean duration of hospital stay (0.0% increase in geometric mean, 95% CI: -3.9 to 4.1%, P=0.957; I2=7.4%; four trials; 7550 patients) compared with the transfusion of older RBCs.
Conclusions: The transfusion of fresher RBCs compared with older RBCs was not associated to better clinical outcomes in critically ill adults.
Keywords: Critically ill; Críticamente enfermo; Glóbulo rojo; Intensive care unit; Mortalidad; Mortality; Red blood cell; Transfusion; Transfusión; Unidad de cuidados intensivos.
Copyright © 2018 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.
Similar articles
- Effects of shorter versus longer storage time of transfused red blood cells in adult ICU patients: a systematic review with meta-analysis and Trial Sequential Analysis.
Rygård SL, Jonsson AB, Madsen MB, Perner A, Holst LB, Johansson PI, Wetterslev J. Rygård SL, et al. Intensive Care Med. 2018 Feb;44(2):204-217. doi: 10.1007/s00134-018-5069-0. Epub 2018 Jan 25. Intensive Care Med. 2018. PMID: 29372291 - The Age of BLood Evaluation (ABLE) randomised controlled trial: description of the UK-funded arm of the international trial, the UK cost-utility analysis and secondary analyses exploring factors associated with health-related quality of life and health-care costs during the 12-month follow-up.
Walsh TS, Stanworth S, Boyd J, Hope D, Hemmatapour S, Burrows H, Campbell H, Pizzo E, Swart N, Morris S. Walsh TS, et al. Health Technol Assess. 2017 Oct;21(62):1-118. doi: 10.3310/hta21620. Health Technol Assess. 2017. PMID: 29067906 Free PMC article. Clinical Trial. - Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia.
Shi Z, Xie H, Wang P, Zhang Q, Wu Y, Chen E, Ng L, Worthington HV, Needleman I, Furness S. Shi Z, et al. Cochrane Database Syst Rev. 2013 Aug 13;(8):CD008367. doi: 10.1002/14651858.CD008367.pub2. Cochrane Database Syst Rev. 2013. PMID: 23939759 Updated. Review. - The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.
Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Tucci M, et al. Trials. 2018 Jul 28;19(1):404. doi: 10.1186/s13063-018-2809-y. Trials. 2018. PMID: 30055634 Free PMC article.
Cited by
- Anemia of Inflammation with An Emphasis on Chronic Kidney Disease.
Begum S, Latunde-Dada GO. Begum S, et al. Nutrients. 2019 Oct 11;11(10):2424. doi: 10.3390/nu11102424. Nutrients. 2019. PMID: 31614529 Free PMC article. Review. - The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine.
Premont RT, Singel DJ, Stamler JS. Premont RT, et al. Mol Aspects Med. 2022 Apr;84:101056. doi: 10.1016/j.mam.2021.101056. Epub 2021 Nov 28. Mol Aspects Med. 2022. PMID: 34852941 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources