Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia - PubMed (original) (raw)
. 2018 Nov;24(11):1677-1682.
doi: 10.1038/s41591-018-0175-7. Epub 2018 Sep 24.
Peter J Grahn 2, Jonathan S Calvert 3, Margaux B Linde 1, Igor A Lavrov 2 4 5, Jeffrey A Strommen 1, Lisa A Beck 1, Dimitry G Sayenko 6 7, Meegan G Van Straaten 1, Dina I Drubach 2, Daniel D Veith 1, Andrew R Thoreson 1, Cesar Lopez 1, Yury P Gerasimenko 6 8, V Reggie Edgerton 6, Kendall H Lee 9 10 11, Kristin D Zhao 12 13
Affiliations
- PMID: 30250140
- DOI: 10.1038/s41591-018-0175-7
Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia
Megan L Gill et al. Nat Med. 2018 Nov.
Erratum in
- Publisher Correction: Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.
Gill ML, Grahn PJ, Calvert JS, Linde MB, Lavrov IA, Strommen JA, Beck LA, Sayenko DG, Van Straaten MG, Drubach DI, Veith DD, Thoreson AR, Lopez C, Gerasimenko YP, Edgerton VR, Lee KH, Zhao KD. Gill ML, et al. Nat Med. 2018 Dec;24(12):1942. doi: 10.1038/s41591-018-0248-7. Nat Med. 2018. PMID: 30353100
Abstract
Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor paralysis of the lower extremities in which EES restored the ability to stand and the ability to control step-like activity while side-lying or suspended vertically in a body-weight support system (BWS)4. Since then, dynamic task-specific training in the presence of EES, termed multimodal rehabilitation (MMR), was performed for 43 weeks and resulted in bilateral stepping on a treadmill, independent from trainer assistance or BWS. Additionally, MMR enabled independent stepping over ground while using a front-wheeled walker with trainer assistance at the hips to maintain balance. Furthermore, MMR engaged sensorimotor networks to achieve dynamic performance of standing and stepping. To our knowledge, this is the first report of independent stepping enabled by task-specific training in the presence of EES by a human with complete loss of lower extremity sensorimotor function due to SCI.
Comment in
- Spinal stimulation and physical therapy helps paraplegic patients to walk again.
Ridler C. Ridler C. Nat Rev Neurol. 2018 Nov;14(11):631. doi: 10.1038/s41582-018-0092-x. Nat Rev Neurol. 2018. PMID: 30337661 No abstract available.
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