Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes - PubMed (original) (raw)
. 1987 Jan;325(7000):125-30.
doi: 10.1038/325125a0.
- PMID: 3027582
- DOI: 10.1038/325125a0
Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes
T Saito et al. Nature. 1987 Jan.
Abstract
The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.
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