Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes - PubMed (original) (raw)

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes

F Gotch et al. J Exp Med. 1987.

Abstract

Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells.

PubMed Disclaimer

Similar articles

• Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein-specific cytotoxic T lymphocytes.
  Anderson RW, Bennink JR, Yewdell JW, Maloy WL, Coligan JE. Anderson RW, et al. Mol Immunol. 1992 Sep;29(9):1089-96. doi: 10.1016/0161-5890(92)90041-u. Mol Immunol. 1992. PMID: 1495499
• Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.
  Yewdell JW, Bennink JR, Smith GL, Moss B. Yewdell JW, et al. Proc Natl Acad Sci U S A. 1985 Mar;82(6):1785-9. doi: 10.1073/pnas.82.6.1785. Proc Natl Acad Sci U S A. 1985. PMID: 3872457 Free PMC article.
• Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2.
  Gotch F, Rothbard J, Howland K, Townsend A, McMichael A. Gotch F, et al. Nature. 1987 Apr 30-May 6;326(6116):881-2. doi: 10.1038/326881a0. Nature. 1987. PMID: 2437457
• Recognition of influenza virus proteins by cytotoxic T lymphocytes.
  Townsend AR. Townsend AR. Immunol Res. 1987;6(1-2):80-100. doi: 10.1007/BF02918106. Immunol Res. 1987. PMID: 2442273 Review. No abstract available.
• Cytotoxic T cells in influenza infection.
  Askonas BA, Taylor PM, Esquivel F. Askonas BA, et al. Ann N Y Acad Sci. 1988;532:230-7. doi: 10.1111/j.1749-6632.1988.tb36342.x. Ann N Y Acad Sci. 1988. PMID: 2845845 Review. No abstract available.

Cited by

• Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.
  Sridhar S. Sridhar S. Front Immunol. 2016 May 19;7:195. doi: 10.3389/fimmu.2016.00195. eCollection 2016. Front Immunol. 2016. PMID: 27242800 Free PMC article. Review.
• Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.
  Murray RJ, Kurilla MG, Brooks JM, Thomas WA, Rowe M, Kieff E, Rickinson AB. Murray RJ, et al. J Exp Med. 1992 Jul 1;176(1):157-68. doi: 10.1084/jem.176.1.157. J Exp Med. 1992. PMID: 1319456 Free PMC article.
• Cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite): a comparison of T- and B-cell antigen recognition.
  O'Hehir RE, Young DB, Kay AB, Lamb JR. O'Hehir RE, et al. Immunology. 1987 Dec;62(4):635-40. Immunology. 1987. PMID: 2448229 Free PMC article.
• Cross-reactive, cell-mediated immunity and protection of chickens from lethal H5N1 influenza virus infection in Hong Kong poultry markets.
  Seo SH, Webster RG. Seo SH, et al. J Virol. 2001 Mar;75(6):2516-25. doi: 10.1128/JVI.75.6.2516-2525.2001. J Virol. 2001. PMID: 11222674 Free PMC article.
• Human cytotoxic T lymphocytes directed to seasonal influenza A viruses cross-react with the newly emerging H7N9 virus.
  van de Sandt CE, Kreijtz JH, de Mutsert G, Geelhoed-Mieras MM, Hillaire ML, Vogelzang-van Trierum SE, Osterhaus AD, Fouchier RA, Rimmelzwaan GF. van de Sandt CE, et al. J Virol. 2014 Feb;88(3):1684-93. doi: 10.1128/JVI.02843-13. Epub 2013 Nov 20. J Virol. 2014. PMID: 24257602 Free PMC article.

References

1. 1. Eur J Immunol. 1977 Sep;7(9):630-5 - PubMed
2. 1. J Exp Med. 1986 Nov 1;164(5):1397-406 - PubMed
3. 1. J Immunol. 1979 Feb;122(2):660-4 - PubMed
4. 1. Adv Immunol. 1979;27:51-177 - PubMed
5. 1. N Engl J Med. 1983 Jul 7;309(1):13-7 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program