Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study - PubMed (original) (raw)

. 2018 Nov 27;31(11):1221-1229.

doi: 10.1515/jpem-2018-0120.

Augusto César Ferreira de Moraes 1 3, Francisco Leonardo Torres-Leal 4, Yannis Manios 5, Frederic Gottand 6, Michael Sjöström 7, Anthony Kafatos 8, Kurt Widhalm 9 10, Stefaan De Henauw 11 12, Dénes Molnár 13, Ascensión Marcos 14, Marcela González-Gross 15 16, Marika Ferrari 17, Heráclito B Carvalho 1, Luis A Moreno 2 18; HELENA study group

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Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study

Tara Rendo-Urteaga et al. J Pediatr Endocrinol Metab. 2018.

Abstract

Background Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods A sample of 511 adolescents with EP (12.5-17.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed. Results EP was positively associated with the atherogenic index (Ath-I) (β=0.174; 95%CI 0.029-0.265) and negatively associated with the C-reactive protein (CRP) (β=-0.284; 95%CI -0.542 to -0.028) in girls. These associations were fully mediated by leptin levels (9.5%) and adiposity (44%), respectively. Moreover, EP has indirect effects on the apolipoprotein A-1 (ApoA-1) levels through adiposity in girls (for body mass index [BMI], β=0.014; 95%CI 0.005-0.028, and for waist circumference [WC], β=0.011; 95%CI 0.003-0.024), and on ApoA-1 (β=0.012; 95%CI 0.004-0.025), apolipoprotein B (ApoB) (β=-0.004; 95%CI -0.011 to -0.0004) and CRP (β=-0.265; 95%CI -0.819 to -0.047) through abdominal fat in boys. Conclusions Leptin levels and adiposity seem to play an important indirect and mediation role in the association between EP and cardiometabolic and inflammatory markers in adolescents. Weight control should be recommended in order to control the impaired cardiometabolic and inflammatory status arising in early pubertal adolescents.

Keywords: adiposity; adolescents; early puberty; indirect effect; leptin; mediation.

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