Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes - PubMed (original) (raw)

. 1987 Jun;327(6123):629-32.

doi: 10.1038/327629a0.

PMID: 3037375
DOI: 10.1038/327629a0

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

J C Cambier et al. Nature. 1987 Jun.

Abstract

Altered subcellular distribution and activity of protein kinase C (PKC) is associated with transmembrane signalling in a variety of systems in which receptor occupancy leads to increased hydrolysis of polyphosphoinositides. Here we report evidence that in B lymphocytes, cyclic-cAMP-generating signal transduction pathways can activate translocation of PKC from the cytosol to the nucleus. Elevated cAMP levels and translocation of PKC to the nucleus are induced by antibodies against Ia antigens in normal B lymphocytes. Further, cAMP analogues mediate the translocation of PKC to the nucleus of these cells. These findings suggest that in physiological situations, ligation of B-lymphocyte Ia molecules by helper T cells leads to increased cAMP production which in turn causes PKC translocation to the nucleus. In view of recent observations that antibodies against Ia antigens induce differentiation of B cells, we conclude that nuclear PKC may function in the regulation of gene expression.

PubMed Disclaimer

Cited by

Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes.
Bishop GA, McMillan MS, Haughton G, Frelinger JA. Bishop GA, et al. Immunogenetics. 1988;28(3):184-92. doi: 10.1007/BF00375858. Immunogenetics. 1988. PMID: 3137158
Properties of protein kinase C associated with nuclear membranes.
Buchner K, Otto H, Hilbert R, Lindschau C, Haller H, Hucho F. Buchner K, et al. Biochem J. 1992 Sep 1;286 ( Pt 2)(Pt 2):369-75. doi: 10.1042/bj2860369. Biochem J. 1992. PMID: 1530569 Free PMC article.
Two distinct pathways of human macrophage differentiation are mediated by interferon-gamma and interleukin-10.
Orlikowsky T, Wang ZQ, Dudhane A, Horowitz H, Conti B, Hoffmann MK. Orlikowsky T, et al. Immunology. 1997 May;91(1):104-8. doi: 10.1046/j.1365-2567.1997.00204.x. Immunology. 1997. PMID: 9203972 Free PMC article.
The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.
Greif H, Ben-Chaim J, Shimon T, Bechor E, Eldar H, Livneh E. Greif H, et al. Mol Cell Biol. 1992 Mar;12(3):1304-11. doi: 10.1128/mcb.12.3.1304-1311.1992. Mol Cell Biol. 1992. PMID: 1545811 Free PMC article.
Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.
Matsumoto AK, Kopicky-Burd J, Carter RH, Tuveson DA, Tedder TF, Fearon DT. Matsumoto AK, et al. J Exp Med. 1991 Jan 1;173(1):55-64. doi: 10.1084/jem.173.1.55. J Exp Med. 1991. PMID: 1702139 Free PMC article.

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes - PubMed (original) (raw)