Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells - PubMed (original) (raw)
Case Reports
Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells
W J Kupsky et al. Neurology. 1987 Jul.
Abstract
Concentric hyaline inclusions (Lewy bodies), found in the cytoplasm of pigmented and nonpigmented neurons, are considered characteristic of idiopathic Parkinson's disease. The finding of cytoplasmic inclusions identical to Lewy bodies in ganglion cells of the colonic myenteric plexus in a patient with idiopathic Parkinson's disease and acquired megacolon suggests primary involvement of the enteric nervous system by Parkinson's disease.
Similar articles
- Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease.
Qualman SJ, Haupt HM, Yang P, Hamilton SR. Qualman SJ, et al. Gastroenterology. 1984 Oct;87(4):848-56. Gastroenterology. 1984. PMID: 6088351 - Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses.
Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F. Wakabayashi K, et al. Acta Neuropathol. 1988;76(3):217-221. doi: 10.1007/BF00687767. Acta Neuropathol. 1988. PMID: 2850698 - Lewy bodies in the enteric nervous system in Parkinson's disease.
Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F. Wakabayashi K, et al. Arch Histol Cytol. 1989;52 Suppl:191-4. doi: 10.1679/aohc.52.suppl_191. Arch Histol Cytol. 1989. PMID: 2554944 Review. - Parkinson's disease and dementia with neuronal inclusions in the cerebral cortex: Lewy bodies or Pick bodies.
Tiller-Borcich JK, Forno LS. Tiller-Borcich JK, et al. J Neuropathol Exp Neurol. 1988 Sep;47(5):526-35. doi: 10.1097/00005072-198809000-00004. J Neuropathol Exp Neurol. 1988. PMID: 2845001 - Idiopathic Parkinson's disease and the Lewy body disorders.
Gibb WR. Gibb WR. Neuropathol Appl Neurobiol. 1986 May-Jun;12(3):223-34. doi: 10.1111/j.1365-2990.1986.tb00136.x. Neuropathol Appl Neurobiol. 1986. PMID: 3016582 Review.
Cited by
- A guide to neurotoxic animal models of Parkinson's disease.
Tieu K. Tieu K. Cold Spring Harb Perspect Med. 2011 Sep;1(1):a009316. doi: 10.1101/cshperspect.a009316. Cold Spring Harb Perspect Med. 2011. PMID: 22229125 Free PMC article. Review. - Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects.
Beach TG, Corbillé AG, Letournel F, Kordower JH, Kremer T, Munoz DG, Intorcia A, Hentz J, Adler CH, Sue LI, Walker J, Serrano G, Derkinderen P. Beach TG, et al. J Parkinsons Dis. 2016 Oct 19;6(4):761-770. doi: 10.3233/JPD-160888. J Parkinsons Dis. 2016. PMID: 27589538 Free PMC article. - Brain-gut-microbiota axis in Parkinson's disease.
Mulak A, Bonaz B. Mulak A, et al. World J Gastroenterol. 2015 Oct 7;21(37):10609-20. doi: 10.3748/wjg.v21.i37.10609. World J Gastroenterol. 2015. PMID: 26457021 Free PMC article. Review. - Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.
Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A. Forsyth CB, et al. PLoS One. 2011;6(12):e28032. doi: 10.1371/journal.pone.0028032. Epub 2011 Dec 1. PLoS One. 2011. PMID: 22145021 Free PMC article. - Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.
Travagli RA, Browning KN, Camilleri M. Travagli RA, et al. Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):673-685. doi: 10.1038/s41575-020-0339-z. Epub 2020 Jul 31. Nat Rev Gastroenterol Hepatol. 2020. PMID: 32737460 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical