POMC Neurons: Feeding, Energy Metabolism, and Beyond - PubMed (original) (raw)

Review

POMC Neurons: Feeding, Energy Metabolism, and Beyond

Cheng Zhan. Adv Exp Med Biol. 2018.

Abstract

The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are three key components of the central melanocortin pathway. This chapter focuses on the Pomc gene and the POMC neural system. First, I summarize the established role of this system in inhibiting food intake. Second, in light of new cutting-edge techniques, our understanding of how POMC neurons function to regulate energy homeostasis has been refined during the last few years. I describe some recent advances and discuss bidirectional effects of POMC neurons on feeding. Finally, the physiological significance beyond energy metabolism, in particular for reward and sex, is also discussed.

Keywords: Arcuate nucleus; Feeding behavior; Nucleus tractus solitarius; POMC neurons; Reward; α-MSH; β-Endorphin.

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POMC Neurons: Feeding, Energy Metabolism, and Beyond - PubMed (original) (raw)