Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women-A 12-Week Placebo-Controlled and Randomized Clinical Study - PubMed (original) (raw)

Randomized Controlled Trial

. 2018 Nov 5;10(11):1672.

doi: 10.3390/nu10111672.

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Randomized Controlled Trial

Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women-A 12-Week Placebo-Controlled and Randomized Clinical Study

Monika Szulińska et al. Nutrients. 2018.

Abstract

Obesity in the postmenopausal period is associated with an increased risk of cardiovascular diseases in women. One of the key drivers of cardiovascular risk is endothelial dysfunction; thus, this is also a crucial point for studies on new therapeutic methods of cardioprotective properties. The aim of the current study was to evaluate the effect of two doses of multispecies probiotic Ecologic® Barrier supplement on functional (primary endpoint) and biochemical parameters (secondary endpoint) of endothelial dysfunction in obese postmenopausal women in a 12-week randomized, placebo-controlled clinical trial. A total of 81 obese Caucasian women participated in the trial. The subjects were randomly assigned to three groups that received a placebo, a low dose (LD) (2.5 × 10⁸ colony forming units (CFU) per day), or a high dose (HD) (1 × 1010 CFU per day) of lyophilisate powder containing live multispecies probiotic bacteria. The probiotic supplement was administered each day for 12 weeks in two equal portions. A high dose probiotic supplementation for 12 weeks decreased systolic blood pressure, vascular endothelial growth factor, pulse wave analysis systolic pressure, pulse wave analysis pulse pressure, pulse wave analysis augmentation index, pulse wave velocity, interleukin-6, tumor necrosis factor alpha, and thrombomodulin. Low doses of probiotic supplementation decreased the systolic blood pressure and interleukin-6 levels. The mean changes in the estimated parameters, compared among the three groups, revealed significant differences in the vascular endothelial growth factor, the pulse wave analysis systolic pressure, the pulse wave analysis augmentation index, the pulse wave velocity, the tumor necrosis factor alpha, and thrombomodulin. The post hoc tests showed significant differences for all parameters between HD and the placebo group, and HD and LD (besides pulse wave analysis augmentation index). We show for the first time that supplementation with multispecies probiotic Ecologic® Barrier favorably modifies both functional and biochemical markers of vascular dysfunction in obese postmenopausal women.

Keywords: arterial stiffness; endothelium; postmenopausal women; probiotics.

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Conflict of interest statement

I.Ł. is a foundation shareholder in Sanprobi, a probiotics distributor. However, the content of this study was not constrained by this fact. Moreover, our adherence to Nutrients’ policies on the sharing of data and materials was unaffected. The other authors have no conflicts of interest to declare.

Figures

Figure 1

Figure 1

A flowchart of the study design.

Figure 2

Figure 2

The comparison of the functional parameters in the high dose (HD), low dose (LD), and placebo groups at the beginning of the study and after three months of probiotic supplementation. Significant differences are highlighted showing the _p_-value. Data are the arithmetic mean ± SD; (a) SBP: systolic blood pressure; (b) PWA SP: pulse wave analysis systolic pressure; (c) PWV: pulse wave velocity; (d) PWA Alx: pulse wave analysis augmentation index; (e) PVV: pulse wave velocity.

Figure 3

Figure 3

The comparison of the biochemical parameters in the high dose (HD), low dose (LD), and placebo groups at the beginning of the study and after three months of probiotic supplementation. Significant differences are highlighted showing the _p_-value. Data are arithmetic mean ± SD; (a) Il-6: interleukin-6; (b) VEGF: vascular endothelial growth factor; (c) TNF: tumor necrosis factor alpha; (d) TM: thrombomodulin.

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