Free radical modification of low-density lipoprotein: mechanisms and biological consequences - PubMed (original) (raw)
Review
Free radical modification of low-density lipoprotein: mechanisms and biological consequences
J W Heinecke. Free Radic Biol Med. 1987.
Abstract
Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density lipoprotein show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells in culture. In this review, free radical mechanisms and the biological consequences of low-density lipoprotein modification are discussed.