B-raf, a new member of the raf family, is activated by DNA rearrangement - PubMed (original) (raw)

B-raf, a new member of the raf family, is activated by DNA rearrangement

S Ikawa et al. Mol Cell Biol. 1988 Jun.

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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References

1. 1. Nucleic Acids Res. 1976 Sep;3(9):2303-8 - PubMed
2. 1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
3. 1. Cell. 1978 Oct;15(2):687-701 - PubMed
4. 1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
5. 1. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402 - PubMed

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