Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype - PubMed (original) (raw)
Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype
M Ballin et al. Biochem Biophys Res Commun. 1988.
Abstract
We have previously demonstrated that activated ras oncogenes can induce the metastatic phenotype and type IV collagenolytic activity in NIH/3T3 cells (Thorgeirsson et al. Mol. Cell. Biol. 5:259-262, 1985). The present study demonstrates ras-mediated induction of a 92 kDa metalloproteinase, which degrades gelatin and type IV collagen. Association of the 92 kDa proteinase expression with the malignant phenotype was also observed in human tumor cell lines. Our data indicate that the 92 kDa gelatin-collagen IV degrading metalloproteinase is an important participant in the proteolytic process involving tumor cell invasion and metastasis.
Similar articles
- Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.
Garbisa S, Pozzatti R, Muschel RJ, Saffiotti U, Ballin M, Goldfarb RH, Khoury G, Liotta LA. Garbisa S, et al. Cancer Res. 1987 Mar 15;47(6):1523-8. Cancer Res. 1987. PMID: 3028610 - Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene.
LoSardo JE, Goggin BS, Bohoslawec O, Neri A. LoSardo JE, et al. Clin Exp Metastasis. 1995 Jul;13(4):236-48. doi: 10.1007/BF00133479. Clin Exp Metastasis. 1995. PMID: 7606886 - Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues.
Ballin M, Mackay AR, Hartzler JL, Nason A, Pelina MD, Thorgeirsson UP. Ballin M, et al. Clin Exp Metastasis. 1991 Mar-Apr;9(2):179-89. doi: 10.1007/BF01756388. Clin Exp Metastasis. 1991. PMID: 2032422 - Role of the Ha-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review).
Boylan JF, Jackson J, Steiner MR, Shih TY, Duigou GJ, Roszman T, Fisher PB, Zimmer SG. Boylan JF, et al. Anticancer Res. 1990 May-Jun;10(3):717-24. Anticancer Res. 1990. PMID: 2195986 Review. - Ras-responsive genes and tumor metastasis.
Chambers AF, Tuck AB. Chambers AF, et al. Crit Rev Oncog. 1993;4(2):95-114. Crit Rev Oncog. 1993. PMID: 8420573 Review.
Cited by
- Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells.
Nasif S, Colombo M, Uldry AC, Schröder MS, de Brot S, Mühlemann O. Nasif S, et al. NAR Cancer. 2023 Sep 6;5(3):zcad048. doi: 10.1093/narcan/zcad048. eCollection 2023 Sep. NAR Cancer. 2023. PMID: 37681034 Free PMC article. - Distinct Oncogenic Transcriptomes in Human Mammary Epithelial Cells Infected With Cytomegalovirus.
Haidar Ahmad S, Pasquereau S, El Baba R, Nehme Z, Lewandowski C, Herbein G. Haidar Ahmad S, et al. Front Immunol. 2021 Dec 22;12:772160. doi: 10.3389/fimmu.2021.772160. eCollection 2021. Front Immunol. 2021. PMID: 35003089 Free PMC article. - Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models.
Leehy KA, Truong TH, Mauro LJ, Lange CA. Leehy KA, et al. J Steroid Biochem Mol Biol. 2018 Feb;176:88-93. doi: 10.1016/j.jsbmb.2017.04.011. Epub 2017 Apr 23. J Steroid Biochem Mol Biol. 2018. PMID: 28442393 Free PMC article. Review. - Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.
Hammer A, Diakonova M. Hammer A, et al. Adv Exp Med Biol. 2015;846:97-137. doi: 10.1007/978-3-319-12114-7_5. Adv Exp Med Biol. 2015. PMID: 25472536 Free PMC article. Review. - Ergosterol Is the Active Compound of Cultured Mycelium Cordyceps sinensis on Antiliver Fibrosis.
Peng Y, Tao Y, Wang Q, Shen L, Yang T, Liu Z, Liu C. Peng Y, et al. Evid Based Complement Alternat Med. 2014;2014:537234. doi: 10.1155/2014/537234. Epub 2014 Oct 15. Evid Based Complement Alternat Med. 2014. PMID: 25386220 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources