The discovery of nitric oxide as the endogenous nitrovasodilator - PubMed (original) (raw)
Review
The discovery of nitric oxide as the endogenous nitrovasodilator
S Moncada et al. Hypertension. 1988 Oct.
Abstract
Endothelium-derived relaxing factor (EDRF) is a labile humoral agent released by vascular endothelium that mediates the relaxation induced by some vasodilators, including acetylcholine and bradykinin. EDRF also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to vascular endothelium. These actions of EDRF are mediated through stimulation of the soluble guanylate cyclase and the consequent elevation of cyclic guanosine 3',5'-monophosphate. EDRF has been identified as nitric oxide (NO). The pharmacology of NO and EDRF is indistinguishable; furthermore, sufficient NO is released from endothelial cells to account for the biological activities of EDRF. Organic nitrates exert their vasodilator activity following conversion to NO in vascular smooth muscle cells. Thus, NO may be considered the endogenous nitrovasodilator. NO is synthesized by vascular endothelium from the terminal guanido nitrogen atom(s) of the amino acid L-arginine. This indicates the existence of an enzymic pathway in which L-arginine is the endogenous precursor for the synthesis of NO. The discovery of the release of NO by vascular endothelial cells, the biosynthetic pathway leading to its generation, and its interaction with other vasoactive substances opens up new avenues for research into the physiology and pathophysiology of the vessel wall.
Similar articles
- [Nitric oxide-dependent endogenous and exogenous vasodilators. The mechanism of action of nitrates].
Machado AP, Alcântara P. Machado AP, et al. Rev Port Cardiol. 1995 Jan;14(1):61-71. Rev Port Cardiol. 1995. PMID: 7695956 Review. Portuguese. - Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.
Palmer RM, Ferrige AG, Moncada S. Palmer RM, et al. Nature. 1987 Jun 11-17;327(6122):524-6. doi: 10.1038/327524a0. Nature. 1987. PMID: 3495737 - Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters.
Ignarro LJ. Ignarro LJ. Pharm Res. 1989 Aug;6(8):651-9. doi: 10.1023/a:1015926119947. Pharm Res. 1989. PMID: 2510139 Review. - [Endothelium-derived relaxing factor(s): endogenous nitrates in the circulation?].
Lüscher TF, Yang Z, Diederich D, Schneider K, von Segesser L, Siebenmann R, Stulz P, Bühler FR. Lüscher TF, et al. Schweiz Med Wochenschr. 1988 Nov 19;118(46):1724-9. Schweiz Med Wochenschr. 1988. PMID: 3062771 Review. German. - Endothelium-derived nitric oxide relaxes nonvascular smooth muscle.
Buga GM, Gold ME, Wood KS, Chaudhuri G, Ignarro LJ. Buga GM, et al. Eur J Pharmacol. 1989 Feb 14;161(1):61-72. doi: 10.1016/0014-2999(89)90180-5. Eur J Pharmacol. 1989. PMID: 2542037
Cited by
- Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence and 15N-Tracer Studies in Yorkshire Pigs.
Piknova B, Park JW, Tunau-Spencer KJ, Jenkins A, Hellinga DG, Walter PJ, Cai H, Schechter AN. Piknova B, et al. Nutrients. 2024 Aug 13;16(16):2674. doi: 10.3390/nu16162674. Nutrients. 2024. PMID: 39203815 Free PMC article. - Medical Management and Device-Based Therapies in Chronic Heart Failure.
Nguyen AH, Hurwitz M, Abraham J, Blumer V, Flanagan MC, Garan AR, Kanwar M, Kataria R, Kennedy JLW, Kochar A, Hernandez-Montfort J, Pahuja M, Shah P, Sherwood MW, Tehrani BN, Vallabhajosyula S, Kapur NK, Sinha SS. Nguyen AH, et al. J Soc Cardiovasc Angiogr Interv. 2023 Dec 4;2(6Part B):101206. doi: 10.1016/j.jscai.2023.101206. eCollection 2023 Nov-Dec. J Soc Cardiovasc Angiogr Interv. 2023. PMID: 39131076 Free PMC article. Review. - The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis.
Csoma B, Bikov A. Csoma B, et al. Int J Mol Sci. 2023 Sep 15;24(18):14145. doi: 10.3390/ijms241814145. Int J Mol Sci. 2023. PMID: 37762448 Free PMC article. Review. - Therapeutic gas-releasing nanomedicines with controlled release: Advances and perspectives.
Opoku-Damoah Y, Zhang R, Ta HT, Xu ZP. Opoku-Damoah Y, et al. Exploration (Beijing). 2022 May 25;2(5):20210181. doi: 10.1002/EXP.20210181. eCollection 2022 Oct. Exploration (Beijing). 2022. PMID: 37325503 Free PMC article. Review. - Potential mechanism of transient receptor potential cation channel subfamily V member 1 combined with an ATP‑sensitive potassium channel in severe preeclampsia.
Zhou X, Lin H, Wei L, Tan Y, Fu X. Zhou X, et al. Exp Ther Med. 2023 May 15;26(1):318. doi: 10.3892/etm.2023.12017. eCollection 2023 Jul. Exp Ther Med. 2023. PMID: 37273761 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous