The amyloid precursor protein (APP) processing as a biological link between Alzheimer's disease and cancer - PubMed (original) (raw)

Review

The amyloid precursor protein (APP) processing as a biological link between Alzheimer's disease and cancer

Fernando Galvão Jr et al. Ageing Res Rev. 2019 Jan.

Abstract

Aging is a risk factor for several illnesses, such as Alzheimer's Disease and various cancers. However, an inverse correlation between malignancies and Alzheimer's Disease has been suggested. This review addressed the potential role of non-amyloidogenic and amyloidogenic pathways of amyloid precursor protein processing as a relevant biochemical mechanism to clarify this association. Amyloidogenic and non-amyloidogenic pathways have been related to Alzheimer's Disease and certain malignancies, respectively. Several known molecules involved in APP processing, including its regulation and final products, were summarized. Among them some candidate mechanisms emerged, such as extracellular-regulated kinase (Erk) and protein kinase C (PKC). Therefore, the imbalance of APP processing may be involved with the negative correlation between cancer and Alzheimer Disease.

Keywords: Aging; Alzheimer disease; Amyloid precursor protein; Amyloidogenic pathway; Cancer; Non- amyloidogenic pathway.

Copyright © 2018 Elsevier B.V. All rights reserved.

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