A controlled trial of stimulant medication in children with the fragile X syndrome - PubMed (original) (raw)

Clinical Trial

. 1988 May-Jun;30(1-2):377-92.

doi: 10.1002/ajmg.1320300138.

Affiliations

• PMID: 3052064
• DOI: 10.1002/ajmg.1320300138

Clinical Trial

A controlled trial of stimulant medication in children with the fragile X syndrome

R J Hagerman et al. Am J Med Genet. 1988 May-Jun.

Abstract

Attentional deficits and hyperactivity frequently are major problems for fra(X) boys. This study evaluated the effectiveness of 2 stimulant medications, methylphenidate and dextroamphetamine compared to placebo in 15 children (13 males, 2 females) with the fra(X) syndrome. A double-blind crossover design was used with outcome measures which included parent and teacher behavior checklists, a controlled observation period, continuous performance tasks and an actometer measure of movement. When the children were treated with methylphenidate only, improvement was seen in socialization skills and attention span according to teacher checklists. Ten children were clinically considered responders and treatment was continued after the study was completed.

PubMed Disclaimer

Similar articles

• Methylphenidate vs dextroamphetamine vs caffeine in minimal brain dysfunction: controlled comparison by placebo washout design with Bayes' analysis.
  Arnold LE, Christopher J, Huestis R, Smeltzer DJ. Arnold LE, et al. Arch Gen Psychiatry. 1978 Apr;35(4):463-73. doi: 10.1001/archpsyc.1978.01770280073008. Arch Gen Psychiatry. 1978. PMID: 365123 Clinical Trial.
• Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline.
  Pelham WE Jr, Greenslade KE, Vodde-Hamilton M, Murphy DA, Greenstein JJ, Gnagy EM, Guthrie KJ, Hoover MD, Dahl RE. Pelham WE Jr, et al. Pediatrics. 1990 Aug;86(2):226-37. Pediatrics. 1990. PMID: 2196522 Clinical Trial.
• An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder.
  Nikles CJ, Mitchell GK, Del Mar CB, Clavarino A, McNairn N. Nikles CJ, et al. Pediatrics. 2006 Jun;117(6):2040-6. doi: 10.1542/peds.2005-1328. Pediatrics. 2006. PMID: 16740846 Clinical Trial.
• Oral folic acid versus placebo in the treatment of males with the fragile X syndrome.
  Hagerman RJ, Jackson AW, Levitas A, Braden M, McBogg P, Kemper M, McGavran L, Berry R, Matus I, Hagerman PJ. Hagerman RJ, et al. Am J Med Genet. 1986 Jan-Feb;23(1-2):241-62. doi: 10.1002/ajmg.1320230119. Am J Med Genet. 1986. PMID: 3513567 Review.
• Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder.
  Stevenson RD, Wolraich ML. Stevenson RD, et al. Pediatr Clin North Am. 1989 Oct;36(5):1183-97. doi: 10.1016/s0031-3955(16)36764-5. Pediatr Clin North Am. 1989. PMID: 2677938 Review.

Cited by

• Advances in the treatment of fragile X syndrome.
  Hagerman RJ, Berry-Kravis E, Kaufmann WE, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Hessl D, Visootsak J, Picker J, Gane L, Tranfaglia M. Hagerman RJ, et al. Pediatrics. 2009 Jan;123(1):378-90. doi: 10.1542/peds.2008-0317. Pediatrics. 2009. PMID: 19117905 Free PMC article. Review.
• Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.
  Berry-Kravis EM, Lindemann L, Jønch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S. Berry-Kravis EM, et al. Nat Rev Drug Discov. 2018 Apr;17(4):280-299. doi: 10.1038/nrd.2017.221. Epub 2017 Dec 8. Nat Rev Drug Discov. 2018. PMID: 29217836 Free PMC article. Review.
• Updated report on tools to measure outcomes of clinical trials in fragile X syndrome.
  Budimirovic DB, Berry-Kravis E, Erickson CA, Hall SS, Hessl D, Reiss AL, King MK, Abbeduto L, Kaufmann WE. Budimirovic DB, et al. J Neurodev Disord. 2017 Jun 12;9:14. doi: 10.1186/s11689-017-9193-x. eCollection 2017. J Neurodev Disord. 2017. PMID: 28616097 Free PMC article. Review.
• Attention/Deficit Hyperactivity Disorder in Adolescent and Young Adult Males With Fragile X Syndrome.
  Klusek J, O'Connor SL, Hickey A, Hills KJ, Abbeduto L, Roberts JE. Klusek J, et al. Am J Intellect Dev Disabil. 2022 May 1;127(3):213-230. doi: 10.1352/1944-7558-127.3.213. Am J Intellect Dev Disabil. 2022. PMID: 35443049 Free PMC article.
• Fragile X syndrome.
  Phillips JP, Wilson GA. Phillips JP, et al. Indian J Pediatr. 1998 Mar-Apr;65(2):181-91. doi: 10.1007/BF02752293. Indian J Pediatr. 1998. PMID: 10771963 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Medical

  • MedlinePlus Health Information