Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome - PubMed (original) (raw)
doi: 10.1016/j.exger.2018.12.005. Epub 2018 Dec 6.
Janos Feher [ 2](#full-view-affiliation-2 "Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Italy."), Gian Luca Scuderi [ 2](#full-view-affiliation-2 "Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Italy."), Dora Szabo 3, Arpad Dobolyi 4, Melinda Cservenak 4, Janos Juhasz 5, Balazs Ligeti 6, Sandor Pongor 5, Mari Carmen Gomez-Cabrera 7, Jose Vina 7, Mitsuru Higuchi 8, Katsuhiro Suzuki 8, Istvan Boldogh 9, Zsolt Radak 10
Affiliations
- PMID: 30529024
- DOI: 10.1016/j.exger.2018.12.005
Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome
Dora Abraham et al. Exp Gerontol. 2019 Jan.
Abstract
It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.
Keywords: Alzheimer; Exercise; Microbiome; Probiotics.
Copyright © 2018. Published by Elsevier Inc.
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