Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy - PubMed (original) (raw)

Review

Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy

Evelyn A Huhn et al. Front Endocrinol (Lausanne). 2018.

Abstract

This review serves to evaluate the screening and diagnostic strategies for gestational diabetes and overt diabetes in pregnancy. We focus on the different early screening and diagnostic approaches in first trimester including fasting plasma glucose, random plasma glucose, oral glucose tolerance test, hemoglobin A1c, risk prediction models and biomarkers. Early screening for gestational diabetes is currently not recommended since the potential benefits and harms of early detection and subsequent treatment need to be further evaluated in randomized controlled trials.

Keywords: diagnostic criteria; early biomarkers; gestational diabetes (GDM); pregnancy; screening.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Overview of tested biomarkers. CRP, c-reactive protein; Free β-HCG, free β-human chorionic gonadotropin; GlyFn; glycosylated fibronectin; HbA1c, hemoglobin A1c; HDL, high density lipoprotein; hsCRP, high sensitive c-reactive protein; IGF, insulin like growth factor; IGFBP, insulin like growth factor binding protein; LDL, low density lipoprotein; MF, maternal factors; PAI-2, plasminogen activator inhibitor-2; PP13, placental protein 13; PAPP-A, pregnancy associated plasma protein-A; PlGF, Placental growth factor; microRNAs, micro ribonucleic acids; sFlt-1, soluble Fms-like tyrosine kinase-1; SHBG, sexual hormone binding globulin; sHLA-G, soluble human leucocyte antigen-G; TNF-α, tumor necrosis factor-α; TSH, thyroid-stimulating hormone; 1.5 AG, 1.5 Anhydroglucitol.

Similar articles

Cited by

References

    1. O'Sullivan JB, Mahan CM. Criteria for the oral glucose tolerance test in pregnancy. Diabetes. (1964) 13:278–85. - PubMed
    1. Yang X, Hsu-Hage B, Zhang H, Zhang C, Zhang Y, Zhang C. Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes. Diabetes Care (2002) 25:1619–24. 10.2337/diacare.25.9.1619 - DOI - PubMed
    1. Vambergue A, Nuttens MC, Verier-Mine O, Dognin C, Cappoen JP, Fontaine P. Is mild gestational hyperglycaemia associated with maternal and neonatal complications? The diagest study. Diabetes Med. (2000) 17:203–8. 10.1046/j.1464-5491.2000.00237.x - DOI - PubMed
    1. Langer O, Brustman L, Anyaegbunam A, Mazze R. The significance of one abnormal glucose tolerance test value on adverse outcome in pregnancy. Am J Obstet Gynecol. (1987) 157:758–63. - PubMed
    1. Sermer M, Naylor CD, Gare DJ, Kenshole AB, Ritchie JW, Farine D, et al. . Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project. Am J Obstet Gynecol. (1995) 173:146–56. - PubMed

Publication types

LinkOut - more resources