[Omega-6/omega-3 ratio and cognition in children with epilepsy] - PubMed (original) (raw)
doi: 10.1016/j.anpedi.2018.07.015. Epub 2019 Jan 16.
[Article in Spanish]
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- PMID: 30660389
- DOI: 10.1016/j.anpedi.2018.07.015
Free article
[Omega-6/omega-3 ratio and cognition in children with epilepsy]
[Article in Spanish]
Karima Abdelfattah Bahagat et al. An Pediatr (Engl Ed). 2019 Aug.
Free article
Abstract
Introduction: Cognitive impairment is a common consequence of epilepsy in children. This study aimed to assess the ratio of omega-6 to omega-3 fatty acid levels and its impact on cognitive function in children with idiopathic epilepsy.
Patients and methods: We performed a case-control study in 30 children with idiopathic epilepsy and 20 healthy children. We measured levels of alpha-linolenic acid (omega-3) and linoleic acid (omega-6) by means of gas-liquid chromatography. We assessed cognitive function with the Arabic version of the fourth edition of the Stanford-Binet test and the P300 component of event-related potentials. All children had an intelligent quotient greater than 70.
Results: Children with epilepsy had lower levels of omega-3 and higher levels of omega-6 fatty acids and an abnormal omega-6/omega-3 ratio compared to non-epileptic children. We found a significant positive correlation of serum omega-3 levels and a significant negative correlation of serum omega-6 levels with cognitive function scores and P300 latency in children with epilepsy.
Conclusion: Children with epilepsy have abnormal ratios of omega-6 to omega-3 fatty acid serum levels, which is associated with impaired cognitive function in these children.
Keywords: Children; Cognición; Cognition; Epilepsia idiopática; Idiopathic epilepsy; Infancia; Omega-3; Omega-6.
Copyright © 2018. Publicado por Elsevier España, S.L.U.
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