Interventions for treating urinary incontinence after stroke in adults - PubMed (original) (raw)

Meta-Analysis

Interventions for treating urinary incontinence after stroke in adults

Lois H Thomas et al. Cochrane Database Syst Rev. 2019.

Abstract

Background: Urinary incontinence can affect 40% to 60% of people admitted to hospital after a stroke, with 25% still having problems when discharged from hospital and 15% remaining incontinent after one year.This is an update of a review published in 2005 and updated in 2008.

Objectives: To assess the effects of interventions for treating urinary incontinence after stroke in adults at least one-month post-stroke.

Search methods: We searched the Cochrane Incontinence and Cochrane Stroke Specialised Registers (searched 30 October 2017 and 1 November 2017 respectively), which contain trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In-Process, MEDLINE Epub Ahead of Print, CINAHL, ClinicalTrials.gov, WHO ICTRP and handsearched journals and conference proceedings.

Selection criteria: We included randomised or quasi-randomised controlled trials.

Data collection and analysis: Two review authors independently undertook data extraction, risk of bias assessment and implemented GRADE.

Main results: We included 20 trials (reporting 21 comparisons) with 1338 participants. Data for prespecified outcomes were not available except where reported below.Intervention versus no intervention/usual careBehavioural interventions: Low-quality evidence suggests behavioural interventions may reduce the mean number of incontinent episodes in 24 hours (mean difference (MD) -1.00, 95% confidence interval (CI) -2.74 to 0.74; 1 trial; 18 participants; P = 0.26). Further, low-quality evidence from two trials suggests that behavioural interventions may make little or no difference to quality of life (SMD -0.99, 95% CI -2.83 to 0.86; 55 participants).Specialised professional input interventions: One trial of moderate-quality suggested structured assessment and management by continence nurse practitioners probably made little or no difference to the number of people continent three months after treatment (risk ratio (RR) 1.28, 95% CI 0.81 to 2.02; 121 participants; equivalent to an increase from 354 to 453 per 1000, 95% CI 287 to 715).Complementary therapy: Five trials assessed complementary therapy using traditional acupuncture, electroacupuncture and ginger-salt-partitioned moxibustion plus routine acupuncture. Low-quality evidence from five trials suggested that complementary therapy may increase the number of participants continent after treatment; participants in the treatment group were three times more likely to be continent (RR 2.82, 95% CI 1.57 to 5.07; 524 participants; equivalent to an increase from 193 to 544 per 1000, 95% CI 303 to 978). Adverse events were reported narratively in one study of electroacupuncture, reporting on bruising and postacupuncture abdominal pain in the intervention group.Physical therapy: Two trials reporting three comparisons suggest that physical therapy using transcutaneous electrical nerve stimulation (TENS) may reduce the mean number of incontinent episodes in 24 hours (MD -4.76, 95% CI -8.10 to -1.41; 142 participants; low-quality evidence). One trial of TENS reporting two comparisons found that the intervention probably improves overall functional ability (MD 8.97, 95% CI 1.27 to 16.68; 81 participants; moderate-quality evidence).Intervention versus placeboPhysical therapy: One trial of physical therapy suggests TPTNS may make little or no difference to the number of participants continent after treatment (RR 0.75, 95% CI 0.19 to 3.04; 54 participants) or number of incontinent episodes (MD -1.10, 95% CI -3.99 to 1.79; 39 participants). One trial suggested improvement in the TPTNS group at 26-weeks (OR 0.04, 95% CI 0.004 to 0.41) but there was no evidence of a difference in perceived bladder condition at six weeks (OR 2.33, 95% CI 0.63 to 8.65) or 12 weeks (OR 1.22, 95% CI 0.29 to 5.17). Data from one trial provided no evidence that TPTNS made a difference to quality of life measured with the ICIQLUTSqol (MD 3.90, 95% CI -4.25 to 12.05; 30 participants). Minor adverse events, such as minor skin irritation and ankle cramping, were reported in one study.Pharmacotherapy interventions: There was no evidence from one study that oestrogen therapy made a difference to the mean number of incontinent episodes per week in mild incontinence (paired samples, MD -1.71, 95% CI -3.51 to 0.09) or severe incontinence (paired samples, MD -6.40, 95% CI -9.47 to -3.33). One study reported no adverse events.Specific intervention versus another interventionBehavioural interventions: One trial comparing a behavioural intervention (timed voiding) with a pharmacotherapy intervention (oxybutynin) contained no useable data.Complementary therapy: One trial comparing different acupuncture needles and depth of needle insertion to assess the effect on incontinence reported that, after four courses of treatment, 78.1% participants in the elongated needle group had no incontinent episodes versus 40% in the filiform needle group (57 participants). This trial was assessed as unclear or high for all types of bias apart from incomplete outcome data.Combined intervention versus single interventionOne trial compared a combined intervention (sensory motor biofeedback plus timed prompted voiding) against a single intervention (timed voiding). The combined intervention may make little or no difference to the number of participants continent after treatment (RR 0.55, 95% CI 0.06 to 5.21; 23 participants; equivalent to a decrease from 167 to 92 per 1000, 95% CI 10 to 868) or to the number of incontinent episodes (MD 2.20, 95% CI 0.12 to 4.28; 23 participants).Specific intervention versus attention controlPhysical therapy interventions: One study found TPTNS may make little or no difference to the number of participants continent after treatment compared to an attention control group undertaking stretching exercises (RR 1.33, 95% CI 0.38 to 4.72; 24 participants; equivalent to an increase from 250 to 333 per 1000, 95% CI 95 to 1000).

Authors' conclusions: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary incontinence after stroke.

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Conflict of interest statement

LT: none known. JC: none known. LC: none known. AT: none known. CW: none known.

Figures

1

1

PRISMA study flow diagram (2019 review update).

2

2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

3

3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

1.1

1.1. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 1 Number of participants continent after treatment.

1.2

1.2. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 2 Number of incontinent episodes in 24 hours (mean).

1.3

1.3. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 3 Number of participants cured of all four urinary symptoms.

1.4

1.4. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 4 Urinary symptoms – frequency (continuous variables).

1.5

1.5. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 5 Urinary symptoms – frequency (dichotomous variables).

1.6

1.6. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 6 Urinary symptoms – urgency.

1.7

1.7. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 7 Urinary symptoms – nocturia (continuous variables).

1.8

1.8. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 8 Urinary symptoms – nocturia (dichotomous variables).

1.9

1.9. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 9 Physical measures: mean function of the pelvic floor muscle.

1.10

1.10. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 10 Health status and quality of life – health status, mean total score 36‐Item Short Form.

1.11

1.11. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 11 Health status and quality of life – quality of life.

1.12

1.12. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 12 Functional ability – mean Barthel score (continuous variables).

1.13

1.13. Analysis

Comparison 1 Intervention versus no intervention/usual care, Outcome 13 Participant satisfaction ‐ numbers who were dissatisfied.

2.1

2.1. Analysis

Comparison 2 Intervention versus placebo, Outcome 1 Number of participants continent after treatment.

2.2

2.2. Analysis

Comparison 2 Intervention versus placebo, Outcome 2 Number of incontinent episodes – mean per day.

2.3

2.3. Analysis

Comparison 2 Intervention versus placebo, Outcome 3 Number of incontinent episodes – mean per week.

2.4

2.4. Analysis

Comparison 2 Intervention versus placebo, Outcome 4 Health status and quality of life – quality of life.

4.1

4.1. Analysis

Comparison 4 Combined intervention versus single intervention, Outcome 1 Number of participants continent after treatment.

4.2

4.2. Analysis

Comparison 4 Combined intervention versus single intervention, Outcome 2 Number of incontinent episodes – mean.

5.1

5.1. Analysis

Comparison 5 Specific intervention versus attention control, Outcome 1 Number of participants continent after treatment.

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ACTRN12617000162314 {published data only}
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NCT02568774 {published data only}
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References to other published versions of this review

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