Incidence and Etiology of Drug-Induced Liver Injury in Mainland China - PubMed (original) (raw)

Multicenter Study

. 2019 Jun;156(8):2230-2241.e11.

doi: 10.1053/j.gastro.2019.02.002. Epub 2019 Feb 8.

Yingxia Liu 2, Jia Shang 3, Qing Xie 4, Jun Li 5, Ming Yan 6, Jianming Xu 7, Junqi Niu 8, Jiajun Liu 9, Paul B Watkins 10, Guruprasad P Aithal 11, Raúl J Andrade 12, Xiaoguang Dou 13, Lvfeng Yao 14, Fangfang Lv 15, Qi Wang 16, Yongguo Li 17, Xinmin Zhou 18, Yuexin Zhang 19, Peilan Zong 20, Bin Wan 21, Zhengsheng Zou 22, Dongliang Yang 23, Yuqiang Nie 24, Dongliang Li 25, Yuya Wang 1, Xi'an Han 26, Hui Zhuang 1, Yimin Mao 27, Chengwei Chen 28

Affiliations

Free article

Multicenter Study

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

Tao Shen et al. Gastroenterology. 2019 Jun.

Free article

Abstract

Background & aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.

Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Investigators at each site were asked to complete causality assessments for each case whose diagnosis at discharge was DILI (n = 29,478) according to the Roussel Uclaf Causality Assessment Method.

Results: Most cases of DILI presented with hepatocellular injury (51.39%; 95% confidence interval [CI] 50.76-52.03), followed by mixed injury (28.30%; 95% CI 27.73-28.87) and cholestatic injury (20.31%; 95% CI 19.80-20.82). The leading single classes of implicated drugs were traditional Chinese medicines or herbal and dietary supplements (26.81%) and antituberculosis medications (21.99%). Chronic DILI occurred in 13.00% of the cases and, although 44.40% of the hepatocellular DILI cases fulfilled Hy's Law criteria, only 280 cases (1.08%) progressed to hepatic failure, 2 cases underwent liver transplantation (0.01%), and 102 patients died (0.39%). Among deaths, DILI was judged to have a primary role in 72 (70.59%), a contributory role in 21 (20.59%), and no role in 9 (8.82%). Assuming the proportion of DILI in the entire hospitalized population of China was represented by that observed in the 66 centers where DILI capture was complete, we estimated the annual incidence in the general population to be 23.80 per 100,000 persons (95% CI 20.86-26.74). Only hospitalized patients were included in this analysis, so the true incidence is likely to be higher.

Conclusions: In a retrospective study to determine the incidence and causes of DILI in mainland China, the annual incidence in the general population was estimated to be 23.80 per 100,000 persons; higher than that reported from Western countries. Traditional Chinese medicines, herbal and dietary supplements, and antituberculosis drugs were the leading causes of DILI in mainland China.

Keywords: Asia; Epidemiology; Jaundice; RUCAM.

Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

LinkOut - more resources