Genomic Imprinting and Physiological Processes in Mammals - PubMed (original) (raw)
Review
. 2019 Feb 21;176(5):952-965.
doi: 10.1016/j.cell.2019.01.043.
Collaborators, Affiliations
- PMID: 30794780
- DOI: 10.1016/j.cell.2019.01.043
Free article
Review
Genomic Imprinting and Physiological Processes in Mammals
Valter Tucci et al. Cell. 2019.
Free article
Abstract
Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role.
Copyright © 2019 Elsevier Inc. All rights reserved.
Similar articles
- Genomic imprinting in mammals.
Barlow DP, Bartolomei MS. Barlow DP, et al. Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2):a018382. doi: 10.1101/cshperspect.a018382. Cold Spring Harb Perspect Biol. 2014. PMID: 24492710 Free PMC article. Review. - New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain.
Perez JD, Rubinstein ND, Dulac C. Perez JD, et al. Annu Rev Neurosci. 2016 Jul 8;39:347-84. doi: 10.1146/annurev-neuro-061010-113708. Epub 2016 Apr 25. Annu Rev Neurosci. 2016. PMID: 27145912 Free PMC article. Review. - Epigenetics: imprinting in plants and mammals--the same but different?
Scott RJ, Spielman M. Scott RJ, et al. Curr Biol. 2004 Mar 9;14(5):R201-3. doi: 10.1016/j.cub.2004.02.022. Curr Biol. 2004. PMID: 15028238 Review. - Genomic imprinting: employing and avoiding epigenetic processes.
Bartolomei MS. Bartolomei MS. Genes Dev. 2009 Sep 15;23(18):2124-33. doi: 10.1101/gad.1841409. Genes Dev. 2009. PMID: 19759261 Free PMC article. - Balanced gene dosage control rather than parental origin underpins genomic imprinting.
Weinberg-Shukron A, Ben-Yair R, Takahashi N, Dunjić M, Shtrikman A, Edwards CA, Ferguson-Smith AC, Stelzer Y. Weinberg-Shukron A, et al. Nat Commun. 2022 Jul 29;13(1):4391. doi: 10.1038/s41467-022-32144-z. Nat Commun. 2022. PMID: 35906226 Free PMC article.
Cited by
- Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism.
Moorwood K, Smith FM, Garfield AS, Cowley M, Holt LJ, Daly RJ, Ward A. Moorwood K, et al. BMC Biol. 2024 Sep 30;22(1):221. doi: 10.1186/s12915-024-02018-5. BMC Biol. 2024. PMID: 39343875 Free PMC article. - PRKACB is a novel imprinted gene in marsupials.
Newman T, Bond DM, Ishihara T, Rizzoli P, Gouil Q, Hore TA, Shaw G, Renfree MB. Newman T, et al. Epigenetics Chromatin. 2024 Sep 28;17(1):29. doi: 10.1186/s13072-024-00552-8. Epigenetics Chromatin. 2024. PMID: 39342354 Free PMC article. - Imprinting as Basis for Complex Evolutionary Novelties in Eutherians.
Schuff M, Strong AD, Welborn LK, Ziermann-Canabarro JM. Schuff M, et al. Biology (Basel). 2024 Aug 31;13(9):682. doi: 10.3390/biology13090682. Biology (Basel). 2024. PMID: 39336109 Free PMC article. Review. - Deciphering DNA Methylation in Gestational Diabetes Mellitus: Epigenetic Regulation and Potential Clinical Applications.
Li N, Liu HY, Liu SM. Li N, et al. Int J Mol Sci. 2024 Aug 29;25(17):9361. doi: 10.3390/ijms25179361. Int J Mol Sci. 2024. PMID: 39273309 Free PMC article. Review. - Prenatal diagnosis of recurrent Kagami-Ogata syndrome inherited from a mother affected by Temple syndrome: a case report and literature review.
Yang X, Li M, Qi Q, Zhou X, Hao N, Lü Y, Jiang Y. Yang X, et al. BMC Med Genomics. 2024 Aug 29;17(1):222. doi: 10.1186/s12920-024-01987-4. BMC Med Genomics. 2024. PMID: 39210340 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
- 210757/Z/18/Z/WT_/Wellcome Trust/United Kingdom
- 210757/Z/18/WT_/Wellcome Trust/United Kingdom
- MR/K011332/1/MRC_/Medical Research Council/United Kingdom
- BB/P002307/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- MR/S000437/1/MRC_/Medical Research Council/United Kingdom
- MR/R022836/1/MRC_/Medical Research Council/United Kingdom
- BBS/E/B/000C0426/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- MR/R009791/1/MRC_/Medical Research Council/United Kingdom
- BB/P008623/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- MR/L010305/1/MRC_/Medical Research Council/United Kingdom
- MR/S00002X/1/MRC_/Medical Research Council/United Kingdom
LinkOut - more resources
Full Text Sources
Other Literature Sources