Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers - PubMed (original) (raw)
- PMID: 3079607
Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers
D E Cavender et al. J Immunol. 1986 Jan.
Abstract
Lymphocyte binding to specialized high-endothelial venules (HEV) in lymph nodes and Peyer's patches is the first step in normal lymphocyte emigration and recirculation. The development and maintenance of HEV in these lymphoid organs are thought to be immunologically controlled. Because postcapillary venules in chronic inflammatory tissue often resemble the HEV of lymphoid tissue and may also be a site of lymphocyte emigration, examination of the effects of immunologic and inflammatory mediators on endothelial cells (EC) may provide important information about the physiology of both normal lymphocyte recirculation and chronic inflammation. It is reported here that treatment of human umbilical vein EC monolayers in vitro with affinity-purified human interleukin 1 (IL 1) markedly enhances the binding of both B and T lymphocytes. Increased binding was observed within 1 h of treatment of EC with as little as 0.04 U/ml IL 1. This effect of IL 1 was EC-specific, because pretreatment of T cells or human skin fibroblasts with IL 1 did not increase the binding of lymphocytes. Stimulation of binding required active EC metabolism because incubation of EC with IL 1 at 4 degrees C, or prior fixation of EC, prevented enhanced binding. The action of IL 1 was not associated with EC damage. The secretion of IL 1 by macrophages and perhaps other cells in inflammatory lesions may exert a positive feedback signal on EC to enhance further emigration of lymphocytes into the inflammatory focus.
Similar articles
- IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils.
Thornhill MH, Kyan-Aung U, Haskard DO. Thornhill MH, et al. J Immunol. 1990 Apr 15;144(8):3060-5. J Immunol. 1990. PMID: 1969883 - Stimulation of mononuclear cell binding to human endothelial cell monolayers by thrombin.
Saegusa Y, Cavender D, Ziff M. Saegusa Y, et al. J Immunol. 1988 Dec 15;141(12):4140-5. J Immunol. 1988. PMID: 3058799 - Pathways to chronic inflammation in rheumatoid synovitis.
Cavender D, Haskard D, Yu CL, Iguchi T, Miossec P, Oppenheimer-Marks N, Ziff M. Cavender D, et al. Fed Proc. 1987 Jan;46(1):113-7. Fed Proc. 1987. PMID: 3100338 Review.
Cited by
- Interferon-gamma modulates messenger RNA levels of c-sis (PDGF-B chain), PDGF-A chain, and IL-1 beta genes in human vascular endothelial cells.
Suzuki H, Shibano K, Okane M, Kono I, Matsui Y, Yamane K, Kashiwagi H. Suzuki H, et al. Am J Pathol. 1989 Jan;134(1):35-43. Am J Pathol. 1989. PMID: 2492403 Free PMC article. - Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis.
Das M, Deb M, Laha D, Joseph M, Kanji S, Aggarwal R, Iwenofu OH, Pompili VJ, Jarjour W, Das H. Das M, et al. Cells. 2019 Aug 16;8(8):908. doi: 10.3390/cells8080908. Cells. 2019. PMID: 31426355 Free PMC article. - Effect of cytokine-induced soluble ICAM-1 from human synovial cells on synovial cell-lymphocyte adhesion.
Shingu M, Hashimoto M, Ezaki I, Nobunaga M. Shingu M, et al. Clin Exp Immunol. 1994 Oct;98(1):46-51. doi: 10.1111/j.1365-2249.1994.tb06605.x. Clin Exp Immunol. 1994. PMID: 7923883 Free PMC article. - Tumor cell-endothelial interactions. Increased adhesion of human melanoma cells to activated vascular endothelium.
Rice GE, Gimbrone MA Jr, Bevilacqua MP. Rice GE, et al. Am J Pathol. 1988 Nov;133(2):204-10. Am J Pathol. 1988. PMID: 3056020 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources