Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents - PubMed (original) (raw)

Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents

Yonghong Fan et al. Biomaterials. 2019 Jun.

Abstract

In-stent restenosis is worsened by thrombosis, acute inflammation, and uncontrollable smooth muscle cells (SMCs) proliferation at the early stage of implantation. Tailoring the stent surface can inhibit thrombosis, intimal hyperplasia, and accelerate re-endothelialization. In situ nitric oxide (NO) generation is considered as a promising method to improve anti-coagulation and anti-hyperplasia abilities. Copper based metal organic frameworks showed great potential as catalysts for NO generation, and copper ion (Cu2+) was demonstrated to promote endothelial cells (ECs) growth. Herein, by using polydopamine as the linker and coating matrix, nanoscale copper-based metal organic frameworks (nano Cu-MOFs) were immobilized onto the titanium surface for simultaneous nitric oxide (NO) catalytic generation and Cu2+ delivery. The nano Cu-MOFs-immobilized coating exhibited desirable NO release and adaptable Cu2+ delivery. Such coating inhibited platelet aggregation and activation via NO-cGMP signaling pathway, and significantly reduced thrombosis in an ex vivo extracorporeal circulation model. NO release and Cu2+ delivery showed synergetic effect to promote EC proliferation. Moreover, SMCs and macrophage proliferation was suppressed by the nano Cu-MOFs-immobilized coating, thereby reducing neointimal hyperplasia in vivo. Overall, this biocompatible coating is convenient for the surface modification of cardiovascular stents and effectively prevents the late stent thrombosis and in-stent restenosis associated with stent implantation.

Keywords: Cardiovascular stent; Copper ion; Metal organic framework; Nitric oxide; Polydopamine.

PubMed Disclaimer

Cited by

Sulfur-Mediated Polycarbonate Polyurethane for Potential Application of Blood-Contacting Materials.
Li P, Cai W, Li X, Zhang H, Zhao Y, Wang J. Li P, et al. Front Bioeng Biotechnol. 2022 Mar 9;10:874419. doi: 10.3389/fbioe.2022.874419. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35356777 Free PMC article.
Preparation of biocompatibility coating on magnesium alloy surface by sodium alginate and carboxymethyl chitosan hydrogel.
Jia R, He Y, Liang J, Duan L, Ma C, Lu T, Liu W, Li S, Wu H, Cao H, Li T, He Y. Jia R, et al. iScience. 2024 Feb 12;27(3):109197. doi: 10.1016/j.isci.2024.109197. eCollection 2024 Mar 15. iScience. 2024. PMID: 38433902 Free PMC article.
Polydopamine-based nanoreactors: synthesis and applications in bioscience and energy materials.
Mei S, Xu X, Priestley RD, Lu Y. Mei S, et al. Chem Sci. 2020 Oct 21;11(45):12269-12281. doi: 10.1039/d0sc04486e. Chem Sci. 2020. PMID: 34094435 Free PMC article. Review.
Inorganic/organic combination: Inorganic particles/polymer composites for tissue engineering applications.
Sharma A, Kokil GR, He Y, Lowe B, Salam A, Altalhi TA, Ye Q, Kumeria T. Sharma A, et al. Bioact Mater. 2023 Jan 11;24:535-550. doi: 10.1016/j.bioactmat.2023.01.003. eCollection 2023 Jun. Bioact Mater. 2023. PMID: 36714332 Free PMC article.
Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment.
Díez-Tercero L, Delgado LM, Bosch-Rué E, Perez RA. Díez-Tercero L, et al. Sci Rep. 2021 Jun 3;11(1):11707. doi: 10.1038/s41598-021-91070-0. Sci Rep. 2021. PMID: 34083604 Free PMC article.

Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents - PubMed (original) (raw)