Dynein activators and adaptors at a glance - PubMed (original) (raw)

Review

Dynein activators and adaptors at a glance

Mara A Olenick et al. J Cell Sci. 2019.

Abstract

Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs. A long-standing question is how a single form of dynein can be adapted to a wide range of cellular functions in both interphase and mitosis. Recent progress has provided new insights - dynein interacts with a group of activating adaptors that provide cargo-specific and/or function-specific regulation of the motor complex. Activating adaptors such as BICD2 and Hook1 enhance the stability of the complex that dynein forms with its required activator dynactin, leading to highly processive motility toward the microtubule minus end. Furthermore, activating adaptors mediate specific interactions of the motor complex with cargos such as Rab6-positive vesicles or ribonucleoprotein particles for BICD2, and signaling endosomes for Hook1. In this Cell Science at a Glance article and accompanying poster, we highlight the conserved structural features found in dynein activators, the effects of these activators on biophysical parameters, such as motor velocity and stall force, and the specific intracellular functions they mediate.

Keywords: BICD2; Cytoplasmic dynein; Dynactin; Hook1; Microtubule motors; Trafficking.

© 2019. Published by The Company of Biologists Ltd.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

Figures

None

References

    1. Abe N., Almenar-Queralt A., Lillo C., Shen Z., Lozach J., Briggs S. P., Williams D. S., Goldstein L. S. B. and Cavalli V. (2009). Sunday driver interacts with two distinct classes of axonal organelles. J. Biol. Chem. 284, 34628-34639. 10.1074/jbc.M109.035022 - DOI - PMC - PubMed
    1. Bachmann-Gagescu R., Dona M., Hetterschijt L., Tonnaer E., Peters T., de Vrieze E., Mans D. A., van Beersum S. E. C., Phelps I. G., Arts H. H. et al. (2015). The ciliopathy protein CC2D2A associates with NINL and functions in RAB8-MICAL3-regulated vesicle trafficking. PLoS Genet. 11, e1005575 10.1371/journal.pgen.1005575 - DOI - PMC - PubMed
    1. Barisic M., Sohm B., Mikolcevic P., Wandke C., Rauch V., Ringer T., Hess M., Bonn G. and Geley S. (2010). Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. Mol. Biol. Cell 21, 1968-1981. 10.1091/mbc.e09-04-0356 - DOI - PMC - PubMed
    1. Baumbach J., Murthy A., McClintock M. A., Dix C. I., Zalyte R., Hoang H. T. and Bullock S. L. (2017). Lissencephaly-1 is a context-dependent regulator of the human dynein complex. Elife 6, e21768 10.7554/eLife.21768 - DOI - PMC - PubMed
    1. Bielska E., Schuster M., Roger Y., Berepiki A., Soanes D. M., Talbot N. J. and Steinberg G. (2014). Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes. J. Cell Biol. 204, 989-1007. 10.1083/jcb.201309022 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources