Stem and progenitor cells in skeletal development - PubMed (original) (raw)

Review

Stem and progenitor cells in skeletal development

Noriaki Ono et al. Curr Top Dev Biol. 2019.

Abstract

Accumulating evidence supports the idea that stem and progenitor cells play important roles in skeletal development. Over the last decade, the definition of skeletal stem and progenitor cells has evolved from cells simply defined by their in vitro behaviors to cells fully defined by a combination of sophisticated approaches, including serial transplantation assays and in vivo lineage-tracing experiments. These approaches have led to better identification of the characteristics of skeletal stem cells residing in multiple sites, including the perichondrium of the fetal bone, the resting zone of the postnatal growth plate, the bone marrow space and the periosteum in adulthood. These diverse groups of skeletal stem cells appear to closely collaborate and achieve a number of important biological functions of bones, including not only bone development and growth, but also bone maintenance and repair. Although these are important findings, we are only beginning to understand the diversity and the nature of skeletal stem and progenitor cells, and how they actually behave in vivo.

Keywords: Bone marrow; Colony-forming unit fibroblasts; Growth plate; In vivo lineage-tracing experiments; Parathyroid hormone; Perichondrium; Periosteum; Skeletal stem cells; Wnt/β-catenin signaling.

© 2019 Elsevier Inc. All rights reserved.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Abad V, Meyers JL, Weise M, Gafni RI, Barnes KM, Nilsson O, et al. (2002). The role of the resting zone in growth plate chondrogenesis. Endocrinology, 143, 1851–1857. - PubMed
    1. Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, et al. (2005). Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proceedings of the National Academy of Sciences of the United States of America, 102, 14665–14670. - PMC - PubMed
    1. Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, et al. (2003). A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. Journal of Immunology, 170, 4649–4655. - PubMed
    1. Balani DH, Ono N, & Kronenberg HM (2017). Parathyroid hormone regulates fates of murine osteoblast precursors in vivo. The Journal of Clinical Investigation, 127, 3327–3338. - PMC - PubMed
    1. Bianco P (2014). “Mesenchymal” stem cells. Annual Review of Cell and Developmental Biology, 30, 677–704. - PubMed

Publication types

MeSH terms

LinkOut - more resources