5-Hydroxytryptamine-2 antagonist increases human slow wave sleep - PubMed (original) (raw)

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5-Hydroxytryptamine-2 antagonist increases human slow wave sleep

C Idzikowski et al. Brain Res. 1986.

Abstract

Ritanserin, a specific 5-HT2 antagonist, was given to volunteers in a double-blind placebo controlled sleep study. Slow wave sleep doubled in duration at the expense of stage 2. The finding that a serotonin antagonist changed the architecture of sleep without producing insomnia is of fundamental importance and calls for a re-examination of traditional theories of sleep control which assign a facilitatory role to serotonin.

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