Multiple nuclear factors interact with the immunoglobulin enhancer sequences - PubMed (original) (raw)
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
R Sen et al. Cell. 1986.
Abstract
To characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers, an electrophoretic mobility shift assay with end-labeled DNA fragments was used. Three binding proteins have been found. One is NF-A, a factor found in all tested cell types that binds to the octamer sequence found upstream of all Ig variable region gene segments and to the same octamer in the heavy chain enhancer. The second, also ubiquitous, protein binds to a sequence in both the heavy chain and the kappa enhancers that was previously shown to be protected from methylation in vivo. Other closely related sites do not compete for this binding, implying a restriction enzyme-like binding specificity. The third protein binds to a sequence in the kappa enhancer (and to an identical sequence in the SV40 enhancer) and is restricted in its occurrence to B cells.
Republished in
- Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716.
Sen R, Baltimore D. Sen R, et al. J Immunol. 2006 Dec 1;177(11):7485-96. J Immunol. 2006. PMID: 17114415 No abstract available.
Comment in
- A nuclear factor in B cells and beyond.
May MJ. May MJ. J Immunol. 2006 Dec 1;177(11):7483-4. doi: 10.4049/jimmunol.177.11.7483. J Immunol. 2006. PMID: 17114414 Review. No abstract available.
Similar articles
- A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.
Elmaleh N, Matthias P, Schaffner W. Elmaleh N, et al. Eur J Biochem. 1990 Feb 14;187(3):507-13. doi: 10.1111/j.1432-1033.1990.tb15332.x. Eur J Biochem. 1990. PMID: 2105887 - Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.
Lenardo M, Pierce JW, Baltimore D. Lenardo M, et al. Science. 1987 Jun 19;236(4808):1573-7. doi: 10.1126/science.3109035. Science. 1987. PMID: 3109035 - Identification of an octamer-binding site in the mouse kappa light-chain immunoglobulin enhancer.
Currie RA, Roeder RG. Currie RA, et al. Mol Cell Biol. 1989 Oct;9(10):4239-47. doi: 10.1128/mcb.9.10.4239-4247.1989. Mol Cell Biol. 1989. PMID: 2511430 Free PMC article. - Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.
Park K, Atchison ML. Park K, et al. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9804-8. doi: 10.1073/pnas.88.21.9804. Proc Natl Acad Sci U S A. 1991. PMID: 1946405 Free PMC article. - Cell-type specific regulation of a kappa immunoglobulin gene by promoter and enhancer elements.
Queen C, Foster J, Stauber C, Stafford J. Queen C, et al. Immunol Rev. 1986 Feb;89:49-68. doi: 10.1111/j.1600-065x.1986.tb01472.x. Immunol Rev. 1986. PMID: 3081432 Review. No abstract available.
Cited by
- p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation.
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R. Campbell CA, et al. Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. Nat Commun. 2024. PMID: 39242546 Free PMC article. - The role of NF-kappaB in the inflammatory processes related to dental caries, pulpitis, apical periodontitis, and periodontitis-a narrative review.
Chen Z, Lang G, Xu X, Liang X, Han Y, Han Y. Chen Z, et al. PeerJ. 2024 Aug 29;12:e17953. doi: 10.7717/peerj.17953. eCollection 2024. PeerJ. 2024. PMID: 39221277 Free PMC article. Review. - Chronic Heat Stress Induces Oxidative Stress and Induces Inflammatory Injury in Broiler Spleen via TLRs/MyD88/NF-κB Signaling Pathway in Broilers.
Chen H, Wang F, Wu X, Yuan S, Dong H, Zhou C, Feng S, Zhao Z, Si L. Chen H, et al. Vet Sci. 2024 Jul 1;11(7):293. doi: 10.3390/vetsci11070293. Vet Sci. 2024. PMID: 39057977 Free PMC article. - Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function.
Pfefferlé M, Vallelian F. Pfefferlé M, et al. Adv Exp Med Biol. 2024;1459:159-195. doi: 10.1007/978-3-031-62731-6_8. Adv Exp Med Biol. 2024. PMID: 39017844 Review. - O-GlcNAcylation in ischemic diseases.
Shi RR, He TQ, Lin MS, Xu J, Gu JH, Xu H. Shi RR, et al. Front Pharmacol. 2024 May 9;15:1377235. doi: 10.3389/fphar.2024.1377235. eCollection 2024. Front Pharmacol. 2024. PMID: 38783961 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases