Sex Differences in Gut Microbiota - PubMed (original) (raw)

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Sex Differences in Gut Microbiota

Yong Sung Kim et al. World J Mens Health. 2020 Jan.

Abstract

Humans carry numerous symbiotic microorganisms in their body, most of which are present in the gut. Although recent technological advances have produced extensive research data on gut microbiota, there are various confounding factors (e.g., diet, race, medications) to consider. Sex is one of the important variables affecting the gut microbiota, but the association has not yet been sufficiently investigated. Although the results are inconsistent, several animal and human studies have shown sex differences in gut microbiota. Herein, we review these studies to discuss the sex-dependent differences as well as the possible mechanisms involved.

Keywords: Gastrointestinal tract; Gonadal steroid hormones; Microbiota; Sex differences.

Copyright © 2020 Korean Society for Sexual Medicine and Andrology.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1

Fig. 1. Changes in the gut microbiota with time and sex, and the modulatory factors involved. BMI: body mass index.

References

    1. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65. -PMC -PubMed
    1. Sommer F, Bäckhed F. The gut microbiota: masters of host development and physiology. Nat Rev Microbiol. 2013;11:227–238. -PubMed
    1. Shanahan F. The colonic microbiota in health and disease. Curr Opin Gastroenterol. 2013;29:49–54. -PubMed
    1. Fukui H, Xu X, Miwa H. Role of gut microbiota-gut hormone axis in the pathophysiology of functional gastrointestinal disorders. J Neurogastroenterol Motil. 2018;24:367–386. -PMC -PubMed
    1. Osadchiy V, Martin CR, Mayer EA. The gut-brain axis and the microbiome: mechanisms and clinical implications. Clin Gastroenterol Hepatol. 2019;17:322–332. -PMC -PubMed

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