Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency - PubMed (original) (raw)
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
W Schuler et al. Cell. 1986.
Abstract
A process unique to lymphocyte differentiation is the rearrangement of genes encoding antigen-specific receptors on B and T cells. A mouse mutant (C.B-17scid) with severe combined immune deficiency, i.e., that lacks functional B and T cells, shows no evidence of such gene rearrangements. However, rearrangements were detected in Abelson murine leukemia virus-transformed bone marrow cells and in spontaneous thymic lymphomas from C.B-17scid mice. Most of these rearrangements were abnormal: approximately 80% of Igh rearrangements deleted the entire Jh region, and approximately 60% of TCR beta rearrangements deleted the entire J beta 2 region. The deletions appeared to result from faulty D-to-J recombination. No such abnormal rearrangements were detected in transformed tissues from control mice. The scid mutation may adversely affect the recombinase system catalyzing the assembly of antigen receptor genes in developing B and T lymphocytes.
Similar articles
- Defective V-to-J recombination of T cell receptor gamma chain genes in scid mice.
Schuler W, Schuler A, Bosma MJ. Schuler W, et al. Eur J Immunol. 1990 Mar;20(3):545-50. doi: 10.1002/eji.1830200313. Eur J Immunol. 1990. PMID: 2156708 - The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism.
Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. Malynn BA, et al. Cell. 1988 Aug 12;54(4):453-60. doi: 10.1016/0092-8674(88)90066-9. Cell. 1988. PMID: 3135938 - Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints.
Schuler W, Ruetsch NR, Amsler M, Bosma MJ. Schuler W, et al. Eur J Immunol. 1991 Mar;21(3):589-96. doi: 10.1002/eji.1830210309. Eur J Immunol. 1991. PMID: 1849083 - Regulation of genome rearrangement events during lymphocyte differentiation.
Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Alt FW, et al. Immunol Rev. 1986 Feb;89:5-30. doi: 10.1111/j.1600-065x.1986.tb01470.x. Immunol Rev. 1986. PMID: 3081433 Review. - Regulation of antigen receptor gene assembly in lymphocytes.
Oltz EM. Oltz EM. Immunol Res. 2001;23(2-3):121-33. doi: 10.1385/IR:23:2-3:121. Immunol Res. 2001. PMID: 11444378 Review.
Cited by
- Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model.
Pirruccello SJ, Nakamine H, Beisel KW, Kleveland KL, Okano M, Taguchi Y, Davis JR, Mahloch ML, Purtilo DT. Pirruccello SJ, et al. Am J Pathol. 1992 May;140(5):1187-94. Am J Pathol. 1992. PMID: 1580330 Free PMC article. - Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?
Gorantla S, Gendelman HE, Poluektova LY. Gorantla S, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):352-62. doi: 10.1007/s11481-011-9335-y. Epub 2012 Jan 7. J Neuroimmune Pharmacol. 2012. PMID: 22222956 Free PMC article. Review. - V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.
Menetski JP, Gellert M. Menetski JP, et al. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9324-8. doi: 10.1073/pnas.87.23.9324. Proc Natl Acad Sci U S A. 1990. PMID: 1701258 Free PMC article. - SCID-Hu mice immunized with a pneumococcal vaccine produce specific human antibodies and show increased resistance to infection.
Aaberge IS, Michaelsen TE, Rolstad AK, Groeng EC, Solberg P, Løvik M. Aaberge IS, et al. Infect Immun. 1992 Oct;60(10):4146-53. doi: 10.1128/iai.60.10.4146-4153.1992. Infect Immun. 1992. PMID: 1398925 Free PMC article. - The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.
Bosma GC, Davisson MT, Ruetsch NR, Sweet HO, Shultz LD, Bosma MJ. Bosma GC, et al. Immunogenetics. 1989;29(1):54-7. doi: 10.1007/BF02341614. Immunogenetics. 1989. PMID: 2908877 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases