Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy - PubMed (original) (raw)
. 2019 Apr 16;27(3):730-736.e3.
doi: 10.1016/j.celrep.2019.03.075.
Hadar Neuman 2, Oren Ziv 1, Anna Belogolovski 3, Yiftah Barsheshet 1, Naamah Bloch 1, Atara Uzan 1, Roey Lahav 1, Avi Peretz 4, Sigal Frishman 5, Moshe Hod 5, Eran Hadar 5, Yoram Louzoun 3, Orly Avni 1, Omry Koren 6
Affiliations
- PMID: 30995472
- DOI: 10.1016/j.celrep.2019.03.075
Free article
Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy
Meital Nuriel-Ohayon et al. Cell Rep. 2019.
Free article
Abstract
Gestation is accompanied by alterations in the microbial repertoire; however, the mechanisms driving these changes are unknown. Here, we demonstrate a dramatic shift in the gut microbial composition of women and mice during late pregnancy, including an increase in the relative abundance of Bifidobacterium. Using in-vivo-transplanted pellets, we found that progesterone, the principal gestation hormone, affects the microbial community. The effect of progesterone on the richness of several bacteria species, including Bifidobacterium, was also demonstrated in vitro, indicating a direct effect. Altogether, our results delineate a model in which progesterone promotes Bifidobacterium growth during late pregnancy.
Keywords: 16S rRNA; Bifidobacterium; gut microbiota; microbiome; pregnancy; progesterone.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.