Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review - PubMed (original) (raw)

Review

Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

Chang Liu et al. Molecules. 2019.

Abstract

: Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from Aloe vera were summarized. Among these advancements, the structural characteristics of purified polysaccharides were reviewed in detail. Meanwhile, the biological activities of acemannan from Aloe vera determined by in vivo, in vitro and clinical experiments are summarized, and possible mechanisms of these bioactivities were discussed. Moreover, the latest research progress on the use of acemannan in dentistry and wound healing was also summarized in details. The structure-activity relationships of acemannan and its medical applications were discussed. Finally, new perspectives for future research work on acemannan were proposed. In conclusion, this review summarizes the extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan_,_ and provides information for the industrial production and possible applications in dentistry and wound healing in the future.

Keywords: Aloe vera; acemannan; applications; biological activity; polysaccharide; structure.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Schematic representation of extraction, separation purification and structure characterization of acemannan from Aloe vera.

Figure 2

Pharmacological effects of acemannan in vitro and in vivo.

Figure 3

Application of acemannan in dentistry and wound healing.

Figure 4

Acemannan induction of IL-6/-8 expression and p50/DNA binding in gingival fibroblasts via TLR5/ / NF-κB-dependent signaling pathway.

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Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review - PubMed (original) (raw)