Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains - PubMed (original) (raw)

Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains

S J Clark et al. Proc Natl Acad Sci U S A. 1987 Mar.

Abstract

The rat W3/25 antigen was the first marker antigen of helper T lymphocytes to be identified. Subsequently, the human OKT4 antigen (now called CD4) was described, and cell distribution and functional data suggested that W3/25 and OKT4 antigens were homologous. This is now confirmed by the matching of peptide sequences from W3/25 antigen with sequence predicted from rat cDNA clones detected by cross-hybridization with a cDNA probe for human CD4. Analysis of the two sequences suggests an evolutionary origin from a structure with four immunoglobulin-related domains, although only domain 1 at the NH2 terminus meets the standard criteria for an immunoglobulin-related sequence. CD4 domains 2 and 4 contain disulfide bonds but seem like truncated immunoglobulin domains, whereas domain 3 may have a pattern of beta-strands like an immunoglobulin variable domain, but without the disulfide bond.

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References

1. 1. Biochemistry. 1974 Jan 15;13(2):211-22 - PubMed
2. 1. Nature. 1986 Sep 4-10;323(6083):74-6 - PubMed
3. 1. Cell. 1977 Nov;12(3):663-73 - PubMed
4. 1. J Mol Biol. 1978 Mar 25;120(1):97-120 - PubMed
5. 1. J Exp Med. 1978 Sep 1;148(3):664-73 - PubMed

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