Bowel preparation for colonoscopy may decrease the levels of testosterone in Korean men - PubMed (original) (raw)

Bowel preparation for colonoscopy may decrease the levels of testosterone in Korean men

Soo-Hyun Lee et al. Sci Rep. 2019.

Abstract

Although colonoscopy is commonly conducted for medical check-ups in Korea, investigations for the influence of bowel preparation on various health conditions are insufficient. This cross-sectional study investigated whether bowel preparation has an influence on serum levels of testosterone. A total of 1114 men were divided into the bowel preparation group and control groups. The median total and free testosterone levels were significantly lower in the bowel preparation group (14.89 and 0.26 nmol/L, respectively) than in the control groups (15.72 and 0.28 nmol/L, respectively). The level of total testosterone significantly increased with age in the bowel preparation group (r = 0.103). The differences in the levels of total and free testosterone between the 2 groups were more prominent in younger men than in older men. In multivariate regression models, bowel preparation was independently associated with the levels of total and free testosterone. In these models, the interaction between age and bowel preparation was significant for the levels of total and free testosterone. In conclusion, bowel preparation may independently decrease the serum levels of total and free testosterone. The decline in testosterone was more evident in younger men than in older men.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1

Figure 1

Mean levels of total and free testosterone according to dehydration. The levels of total (A) and free testosterone (B) were not significantly different according to dehydration defined by urine specific gravity or ketone body formation in both groups of bowel preparation and control. SG, specific gravity.

Figure 2

Figure 2

Mean levels of total and free testosterone according to age groups. Bowel preparation group had a significantly lower total (A) and free testosterone (B) than the control group in younger age groups (<40 and 40–49 years). However, no significant difference between bowel preparation groups and controls was seen in the older groups.

References

    1. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev. 1987;8:1–28. doi: 10.1210/edrv-8-1-1. - DOI - PubMed
    1. Wilson JD. The role of androgens in male gender role behavior. Endocr Rev. 1999;20:726–737. doi: 10.1210/edrv.20.5.0377. - DOI - PubMed
    1. Baskin HJ, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002;8:457–469. doi: 10.4158/1934-2403-8.6.457. - DOI - PubMed
    1. Lejeune H, Huyghe E, Droupy S. Hypoactive sexual desire and testosterone deficiency in men. Prog Urol. 2013;23:621–628. doi: 10.1016/j.purol.2013.01.019. - DOI - PubMed
    1. Lunenfeld B, Arver S, Moncada I, Rees DA, Schulte HM. How to help the aging male? Current approaches to hypogonadism in primary care. Aging Male. 2012;15:187–197. doi: 10.3109/13685538.2012.729110. - DOI - PubMed

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