Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site - PubMed (original) (raw)

Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site

B Korber et al. Proc Natl Acad Sci U S A. 1987 May.

Abstract

Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2Ld and H-2Dd DNA sequences to control the responses to interferon. The results indicate that interferon regulation of class I gene expression is complex and involves at least two mechanisms that are dependent on class I sequences located upstream and downstream to the transcription initiation site. In transfected mouse L cells, both of these regions are required for full enhancement of class I gene expression, with the major portion of the response controlled by the sequences located 3' to the transcription initiation site. The fine-mapping analysis of the 5' region-encoded response also suggests that recombinant alpha and gamma interferons may exert their effects on class I gene expression by using different cis-acting regulatory sequences.

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References

1. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1284-7 - PubMed
1. Science. 1979 Feb 9;203(4380):516-21 - PubMed
1. Adv Immunol. 1979;27:51-177 - PubMed
1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
1. Methods Enzymol. 1980;65(1):499-560 - PubMed

Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site - PubMed (original) (raw)