A test of neutral molecular evolution based on nucleotide data - PubMed (original) (raw)

A test of neutral molecular evolution based on nucleotide data

R R Hudson et al. Genetics. 1987 May.

Abstract

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.

PubMed Disclaimer

Similar articles

• Adaptive protein evolution at the Adh locus in Drosophila.
  McDonald JH, Kreitman M. McDonald JH, et al. Nature. 1991 Jun 20;351(6328):652-4. doi: 10.1038/351652a0. Nature. 1991. PMID: 1904993
• Excess polymorphism at the Adh locus in Drosophila melanogaster.
  Kreitman ME, Aguadé M. Kreitman ME, et al. Genetics. 1986 Sep;114(1):93-110. doi: 10.1093/genetics/114.1.93. Genetics. 1986. PMID: 3021568 Free PMC article.
• Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila.
  Bodmer M, Ashburner M. Bodmer M, et al. Nature. 1984 May 31-Jun 6;309(5967):425-30. doi: 10.1038/309425a0. Nature. 1984. PMID: 6427630
• The Adh gene promoters of Drosophila melanogaster and Drosophila orena are functionally conserved and share features of sequence structure and nuclease-protected sites.
  Moses K, Heberlein U, Ashburner M. Moses K, et al. Mol Cell Biol. 1990 Feb;10(2):539-48. doi: 10.1128/mcb.10.2.539-548.1990. Mol Cell Biol. 1990. PMID: 2105454 Free PMC article.
• Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies.
  Ashburner M. Ashburner M. Bioessays. 1998 Nov;20(11):949-54. doi: 10.1002/(SICI)1521-1878(199811)20:11<949::AID-BIES10>3.0.CO;2-0. Bioessays. 1998. PMID: 9872061 Review.

Cited by

• Epidemiological Characterization and Genetic Variation of the SARS-CoV-2 Delta Variant in Palestine.
  Ereqat S, Alikhan NF, Al-Jawabreh A, Matthews M, Al-Jawabreh A, de Oliveira Martins L, Trotter AJ, Al-Kaila M, Page AJ, Pallen MJ, Nasereddin A. Ereqat S, et al. Pathogens. 2024 Jun 20;13(6):521. doi: 10.3390/pathogens13060521. Pathogens. 2024. PMID: 38921818 Free PMC article.
• Genome-wide patterns of noncoding and protein-coding sequence variation in the major fungal pathogen Aspergillus fumigatus.
  Brown A, Steenwyk JL, Rokas A. Brown A, et al. G3 (Bethesda). 2024 Jul 8;14(7):jkae091. doi: 10.1093/g3journal/jkae091. G3 (Bethesda). 2024. PMID: 38696662 Free PMC article.
• Independent expansion, selection and hypervariability of the TBC1D3 gene family in humans.
  Guitart X, Porubsky D, Yoo D, Dougherty ML, Dishuck PC, Munson KM, Lewis AP, Hoekzema K, Knuth J, Chang S, Pastinen T, Eichler EE. Guitart X, et al. bioRxiv [Preprint]. 2024 Mar 13:2024.03.12.584650. doi: 10.1101/2024.03.12.584650. bioRxiv. 2024. PMID: 38654825 Free PMC article. Updated. Preprint.
• The extent of introgression between incipient Clarkia species is determined by temporal environmental variation and mating system.
  Sianta SA, Moeller DA, Brandvain Y. Sianta SA, et al. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2316008121. doi: 10.1073/pnas.2316008121. Epub 2024 Mar 11. Proc Natl Acad Sci U S A. 2024. PMID: 38466849 Free PMC article.
• The Impact of Patterns in Linkage Disequilibrium and Sequencing Quality on the Imprint of Balancing Selection.
  Hayeck TJ, Li Y, Mosbruger TL, Bradfield JP, Gleason AG, Damianos G, Shaw GT, Duke JL, Conlin LK, Turner TN, Fernández-Viña MA, Sarmady M, Monos DS. Hayeck TJ, et al. Genome Biol Evol. 2024 Feb 1;16(2):evae009. doi: 10.1093/gbe/evae009. Genome Biol Evol. 2024. PMID: 38302106 Free PMC article.

References

1. 1. Genetics. 1983 Mar;103(3):545-55 - PubMed
2. 1. Theor Popul Biol. 1976 Dec;10(3):254-75 - PubMed
3. 1. Genetics. 1978 Feb;88(2):405-17 - PubMed
4. 1. Theor Popul Biol. 1983 Apr;23(2):183-201 - PubMed
5. 1. Genetics. 1986 Sep;114(1):93-110 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Silverchair Information Systems

• Molecular Biology Databases

  • FlyBase