A test of neutral molecular evolution based on nucleotide data - PubMed (original) (raw)
A test of neutral molecular evolution based on nucleotide data
R R Hudson et al. Genetics. 1987 May.
Abstract
The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.
Similar articles
- Adaptive protein evolution at the Adh locus in Drosophila.
McDonald JH, Kreitman M. McDonald JH, et al. Nature. 1991 Jun 20;351(6328):652-4. doi: 10.1038/351652a0. Nature. 1991. PMID: 1904993 - Excess polymorphism at the Adh locus in Drosophila melanogaster.
Kreitman ME, Aguadé M. Kreitman ME, et al. Genetics. 1986 Sep;114(1):93-110. doi: 10.1093/genetics/114.1.93. Genetics. 1986. PMID: 3021568 Free PMC article. - Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila.
Bodmer M, Ashburner M. Bodmer M, et al. Nature. 1984 May 31-Jun 6;309(5967):425-30. doi: 10.1038/309425a0. Nature. 1984. PMID: 6427630 - The Adh gene promoters of Drosophila melanogaster and Drosophila orena are functionally conserved and share features of sequence structure and nuclease-protected sites.
Moses K, Heberlein U, Ashburner M. Moses K, et al. Mol Cell Biol. 1990 Feb;10(2):539-48. doi: 10.1128/mcb.10.2.539-548.1990. Mol Cell Biol. 1990. PMID: 2105454 Free PMC article. - Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies.
Ashburner M. Ashburner M. Bioessays. 1998 Nov;20(11):949-54. doi: 10.1002/(SICI)1521-1878(199811)20:11<949::AID-BIES10>3.0.CO;2-0. Bioessays. 1998. PMID: 9872061 Review.
Cited by
- Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
Lang M, Murat S, Clark AG, Gouppil G, Blais C, Matzkin LM, Guittard E, Yoshiyama-Yanagawa T, Kataoka H, Niwa R, Lafont R, Dauphin-Villemant C, Orgogozo V. Lang M, et al. Science. 2012 Sep 28;337(6102):1658-61. doi: 10.1126/science.1224829. Science. 2012. PMID: 23019649 Free PMC article. - Dynamics of neutral and selected alleles when the offspring distribution is skewed.
Der R, Epstein C, Plotkin JB. Der R, et al. Genetics. 2012 Aug;191(4):1331-44. doi: 10.1534/genetics.112.140038. Epub 2012 Jun 1. Genetics. 2012. PMID: 22661323 Free PMC article. - Evolutionary origin and demographic history of an ancient conifer (Juniperus microsperma) in the Qinghai-Tibetan Plateau.
Shang HY, Li ZH, Dong M, Adams RP, Miehe G, Opgenoorth L, Mao KS. Shang HY, et al. Sci Rep. 2015 May 15;5:10216. doi: 10.1038/srep10216. Sci Rep. 2015. PMID: 25977142 Free PMC article. - Isolation and diversity analysis of resistance gene homologues from switchgrass.
Zhu Q, Bennetzen JL, Smith SM. Zhu Q, et al. G3 (Bethesda). 2013 Jun 21;3(6):1031-42. doi: 10.1534/g3.112.005447. G3 (Bethesda). 2013. PMID: 23589518 Free PMC article. - Lack of polymorphism on the Drosophila fourth chromosome resulting from selection.
Berry AJ, Ajioka JW, Kreitman M. Berry AJ, et al. Genetics. 1991 Dec;129(4):1111-7. doi: 10.1093/genetics/129.4.1111. Genetics. 1991. PMID: 1686006 Free PMC article.
References
- Genetics. 1983 Mar;103(3):545-55 - PubMed
- Theor Popul Biol. 1976 Dec;10(3):254-75 - PubMed
- Genetics. 1978 Feb;88(2):405-17 - PubMed
- Theor Popul Biol. 1983 Apr;23(2):183-201 - PubMed
- Genetics. 1986 Sep;114(1):93-110 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases